Through tissue imaging of a live breast cancer tumour model using handheld surface enhanced spatially offset resonance Raman spectroscopy (SESORRS)

Chemical Science
Fay NicolsonKaren Faulds

Abstract

In order to improve patient survival and reduce the amount of unnecessary and traumatic biopsies, non-invasive detection of cancerous tumours is of imperative and urgent need. Multicellular tumour spheroids (MTS) can be used as an ex vivo cancer tumour model, to model in vivo nanoparticle (NP) uptake by the enhanced permeability and retention (EPR) effect. Surface enhanced spatially offset Raman spectroscopy (SESORS) combines both surface enhanced Raman spectroscopy (SERS) and spatially offset Raman spectroscopy (SORS) to yield enhanced Raman signals at much greater sub-surface levels. By utilizing a reporter that has an electronic transition in resonance with the laser frequency, surface enhanced resonance Raman scattering (SERRS) yields even greater enhancement in Raman signal. Using a handheld SORS spectrometer with back scattering optics, we demonstrate the detection of live breast cancer 3D MTS containing SERRS active NPs through 15 mm of porcine tissue. False color 2D heat intensity maps were used to determine tumour model location. In addition, we demonstrate the tracking of SERRS-active NPs through porcine tissue to depths of up to 25 mm. This unprecedented performance is due to the use of red-shifted chalcogenpyrylium-...Continue Reading

References

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Citations

May 13, 2018·Biosensors·T Joshua MooreBhavya Sharma
Nov 11, 2020·Chemical Society Reviews·Fay NicolsonPavel Matousek
Sep 4, 2019·ACS Nano·Judith LangerLuis M Liz-Marzán
May 10, 2020·Current Radiopharmaceuticals·Ulku Korkmaz, Funda Ustun
Nov 5, 2021·Chemical Communications : Chem Comm·Sian Sloan-DennisonKaren Faulds
Jan 15, 2022·Chemical Communications : Chem Comm·Matthew E BerryKaren Faulds

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Methods Mentioned

BETA
imaging technique
biopsy
Raman
surface enhanced Raman scattering

Software Mentioned

SESORRS
SORS
SESORS

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