PMID: 7009417Jan 1, 1981Paper

Thy-2: a murine thymocyte-brain alloantigen controlled by a gene linked to the major histocompatibility complex

Immunogenetics
A W Siadak, R C Nowinski

Abstract

We describe a new murine cell-surface alloantigen, provisionally designated Thy-2, which is expressed primarily on thymocytes and brain tissue. Although Thy-2 is also expressed at lower levels on bone-marrow and spleen cells, this antigen does not appear to be present on lymph-node, liver, or red blood cells. Immunoprecipitation of surface-labeled thymocyte extracts from a variety of inbred strains reveals this antigen to be a single polypeptide of 150000 daltons. Quantitative membrane immunofluorescence demonstrates that Thy-2 is a minor cell-surface component which is present on the majority of thymocytes. Mice heterozygous at the Thy-2 locus express approximately 50 percent as much antigen as positive homozygotes. Expression of the Thy-2 alloantigen is controlled by a single semidominant gene located approximately 3 cM to the right of the H-2K locus on chromosome 17.

References

Jun 30, 1975·Annals of the New York Academy of Sciences·M R Loken, L A Herzenber
Jan 1, 1979·Advances in Immunology·I F McKenzie, T Potter
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·H Cantor, E A Boyse
Mar 1, 1979·The Journal of Experimental Medicine·R Dalchau, J W Fabre
Jan 1, 1977·Contemporary Topics in Immunobiology·O Stutman
Jan 17, 1978·Molecular & General Genetics : MGG·E M EicherL Flaherty
Dec 1, 1975·Genetical Research·B A Taylor, H Meier
Jun 20, 1974·Brain Research·M Schachner, U Hämmerling
Jun 11, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E A BoyseL J Old
Aug 1, 1973·The Journal of Experimental Medicine·K Komuro, E A Boyse
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R S Basch, G Goldstein
Sep 1, 1974·European Journal of Immunology·R T ActonA F Williams
Jan 29, 1966·Nature·A E Reif, J M Allen
Sep 1, 1964·The Journal of Experimental Medicine·A E REIF, J M ALLEN

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Citations

Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society
Dec 1, 1982·Biochemical Genetics·J M SzymuraJ Klein
Nov 1, 1988·Immunology Today·K L Holmes, H C Morse
Jun 1, 1983·European Journal of Immunology·C L SidmanK F Lindahl
Apr 1, 1985·Immunological Reviews·C E Hayes, K K Klyczek
Jan 1, 1989·Acta Neurologica Scandinavica. Supplementum·J Carlsen
Feb 1, 1985·The Journal of Experimental Zoology·C M WarnerD J Spannaus
Oct 1, 1984·American Journal of Reproductive Immunology : AJRI·R C StongW H Stone

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