PMID: 7536165Dec 1, 1994Paper

Thy1 (+) and (-) lung fibrosis subpopulations in LEW and F344 rats

The European Respiratory Journal
J C McIntoshJ W Simecka

Abstract

Appreciation of the potential of fibroblasts as effector cells in inflammation has led to the recognition of fibroblast subpopulations, the most stable of which are the Thy1 (+) and Thy1 (-) subpopulations in mouse lung fibroblasts. We investigated the presence of Thy1 (+) and (-) fibroblasts in rats, comparing the percentage in primary cultures from rats with different susceptibility to fibrosis, and whether the characteristics were similar in mice and rats, and between normal and fibrotic rats lungs. Using primary cultures of rat fibroblasts obtained both from normal and fibrotic lungs, we analysed the percentage of Thy1 (+) and (-) fibroblasts by fluorescence-activated cell sorter (FACS) analysis. We sorted the fibroblasts to evaluate immune region associated antigen (Ia) expression, which tends to be raised in tissues involved in inflammation, and other characteristics. We found that Thy1 (+) and (-) fibroblasts: 1) are distinct subpopulations in rat lungs; 2) are found in different proportions in rat strains with different propensity towards lung fibrosis; and 3) have similar but not identical characteristics in mice and rats. We also found that bleomycin-induced fibrosis increases the percentage of Ia expression in Thy1 (...Continue Reading

Citations

Jun 20, 2007·Cell and Tissue Research·Jozsef DudasGiuliano Ramadori
May 30, 2002·American Journal of Respiratory Cell and Molecular Biology·James S HagoodGerald M Fuller
Sep 9, 2006·American Journal of Respiratory Cell and Molecular Biology·Yan Y SandersJames S Hagood
Jun 17, 2008·American Journal of Respiratory Cell and Molecular Biology·Yan Y SandersJames S Hagood
Jan 24, 2012·American Journal of Respiratory Cell and Molecular Biology·Brian M VariscoJames S Hagood
Aug 3, 2004·The Journal of Clinical Investigation·Roderick J PhillipsRobert M Strieter
Oct 15, 2003·The Journal of Cell Biology·Nancy A Rice, Leslie A Leinwand
Dec 17, 2011·The American Journal of the Medical Sciences·Viranuj SueblinvongJesse Roman
Mar 5, 2015·The Journal of Investigative Dermatology·Manuela SchmidtAnja Saalbach
Mar 31, 2007·Journal of Molecular and Cellular Cardiology·François Hudon-DavidGaétan Thibault
Oct 16, 2015·The Journal of Cell Biology·Vincent F FioreThomas H Barker
Aug 19, 2016·United European Gastroenterology Journal·Chao Li, John F Kuemmerle
Mar 22, 2014·Circulation Research·Milena B FurtadoNadia A Rosenthal
Feb 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anja Saalbach, Ulf Anderegg
Jul 11, 2002·American Journal of Physiology. Cell Physiology·Laura Koumas, Richard P Phipps
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael R NazarethRichard B Bankert
Jul 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Takahiro NishioTatiana Kisseleva
Aug 10, 2018·Science Translational Medicine·Ann-Kristin PickeAnja Saalbach

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