Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival

The Journal of Clinical Investigation
Steven R DuncanArgyrios N Theofilopoulos

Abstract

We have demonstrated that murine thymic dendritic cells (DCs) isolated from donor mice have the capability to home to thymi of fully allogeneic recipients after intravenous injections, where they induce T cell deletions and prolong donor-strain airway and skin graft survival. In contrast, infused splenic DCs immigrated poorly to thymi, and did not affect graft survival. These findings suggest that preferential homing may be an important mechanistic difference among subpopulations of DCs that mediate immune functions and illustrate a novel methodology that could have utility for induction of specific immunologic nonreactivity to allografts, or other disease-associated antigens.

References

Feb 22, 1990·The New England Journal of Medicine·A M KrenskyP Parham
Aug 1, 1994·Immunology Today·P G Ashton-Rickardt, S Tonegawa
Feb 12, 1993·Science·S QinH Waldmann
Jun 1, 1996·The Journal of Clinical Investigation·S R DuncanA N Theofilopoulos
Apr 1, 1996·The Journal of Experimental Medicine·G Süss, K Shortman
Jun 1, 1996·The Journal of Experimental Medicine·S OehenS M Hedrick
Oct 1, 1996·Current Opinion in Immunology·A Naji
Mar 1, 1997·International Immunology·P BjörckL Flores-Romo
Jul 1, 1997·Immunology Today·C Ardavín
Jun 20, 1998·Annals of Internal Medicine·L A Turka
Sep 9, 1998·American Journal of Respiratory Cell and Molecular Biology·I P NeuringerR M Aris
Feb 2, 1999·The Journal of Experimental Medicine·R Maldonado-LópezM Moser
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Sep 30, 2000·Immunology Today·S GrabbeG Schuler

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Citations

Jan 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Isabel P NeuringerRobert Aris
Jun 17, 2006·Current Opinion in Immunology·Roberto Bonasio, Ulrich H von Andrian
Nov 10, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jason W ChienSteven Z Pavletic
May 11, 2015·Seminars in Cell & Developmental Biology·Andreas SchlitzerFlorent Ginhoux
Aug 30, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Swati Bhattacharyya, Morton J Cowan

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Methods Mentioned

BETA
scraping
FACS
flow cytometry
dissection
light microscopy
PCR
PCRs
transgenic

Software Mentioned

CellQuest

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