PMID: 6981841Jul 1, 1982Paper

Thymic influences on autoimmunity in MRL-lpr mice

Scandinavian Journal of Immunology
D WofsyN Talal

Abstract

We have examined the role of the thymus in the development of autoimmunity in MRL/Mp-lpr/lpr (MRL-lpr) mice. MRL-lpr mice develop a lymphoproliferative disorder characterized by features of systemic lupus erythematosus and by massive proliferation of a subpopulation of Lyt-1+23- T cells. Using fluorescein-conjugated monoclonal antibodies and the fluorescence-activated cell sorter, we have found an abnormal pattern of differentiation within the MRL-lpr thymus characterized by a loss of Lyt-123+ thymocytes and an increased frequency of Lyt-1+23- thymocytes. Neonatal thymectomy retarded lymphoproliferation, reduced autoantibody concentrations, improved renal function, and prolonged life. Furthermore, neonatal thymectomy resulted in a relatively specific elimination of the subset of T cells involved in the lymphoproliferative process. These findings suggest that thymic maturation of T cells with alloantigenic characteristics of a helper subpopulation may contribute to the marked lymphoproliferation and severe autoimmunity of MRL-lpr mice. Neonatal thymectomy may protect against autoimmunity by preventing the maturation of this helper subpopulation.

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Citations

Dec 1, 1984·Agents and Actions·M L ToivonenH Vapaatalo
Jun 1, 1983·The Journal of Experimental Medicine·G J Prud'hommeA N Theofilopoulos
Oct 1, 1986·The Journal of Experimental Medicine·S E ArantW J Koopman
Mar 23, 2006·Annual Review of Immunology·Nicolas BidèreMichael J Lenardo
Sep 1, 1988·Cellular Immunology·A KarashimaK Nomoto
Dec 1, 1989·Clinical Immunology and Immunopathology·H ArigaD A Sullivan
Feb 1, 1988·The British Journal of Dermatology·J D Bos
Jan 1, 1992·Autoimmunity·T W CroghanP L Cohen
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroaki KomoriMasao Ono
May 12, 1998·Clinical Immunology and Immunopathology·M S ChesnuttD Wofsy

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