PMID: 6966312Apr 1, 1980Paper

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization

The Journal of Experimental Medicine
H WekerleM Ernst

Abstract

We describe a new cellular component of normal mouse thymuses, which is isolated by fractionated trypsin dissociation of minced thymus tissue followed by repeated unit gravity sedimentation. These cells are of unusually large size, with diameters of 30 mum and more. They represent cellular complexes of single large cells filled with high numbers of lymphoid cells. The majority of the engulfed lymphoid cells is not only fully intact, as judged by morphological criteria, but, moreover, includes a high proportion of mitotic figures. Electron microscopic investigations reveal the epithelial character of the large thymic nurse cells (TNC). The peripherally situated cytoplasmic tonofilament streams, and characteristic vacuoles filled with coarse, unidentified material, closely resemble cytoplasmic organelles found in the cortical reticuloepithelial cells described in situ. The internalized lymphocytes are located within caveolae lined by plasma membranes. These TNC caveolae are completely sequestered, and have lost any communication with the extracellular space, as demonstrated by the inability of an electrondense marker, cationized ferritin, to diffuse into the perilymphocytic clefts. The structural interactions between the membrane...Continue Reading

References

Apr 11, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D C Smith
Jan 1, 1979·Scandinavian Journal of Immunology·U ForsumP A Peterson
Oct 1, 1978·The Journal of Experimental Medicine·P P JonesH O McDevitt
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·J J OwenH N Willcox
Jun 1, 1977·European Journal of Immunology·A M KruisbeekJ J Zijlstra
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Jul 1, 1979·The Journal of Experimental Medicine·G J HämmerlingL Flaherty
Jul 21, 1977·Nature·G RowdenA K Sullivan
Jul 21, 1977·Nature·L KlareskogP A Peterson
Dec 14, 1978·Nature·K WimanP A Peterson
Apr 1, 1979·Experimental Cell Research·M L Kapsenberg, W Leene
Jul 1, 1975·Journal of Ultrastructure Research·F HumbertL Orci
Mar 1, 1972·Journal of Ultrastructure Research·D DanonE Skutelsky
Jan 1, 1974·The Journal of Cell Biology·J A McIntyreM J Karnovsky
May 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L A Staehelin
Dec 1, 1972·The Journal of Experimental Medicine·D E Mosier, C W Pierce
Jan 1, 1974·The Journal of Cell Biology·D M Landis, T S Reese
Feb 1, 1969·The Australian Journal of Experimental Biology and Medical Science·T Mandel
Jul 1, 1956·British Journal of Haematology·J G HUMBLER J PULVERTAFT

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Citations

Aug 1, 1997·Microscopy Research and Technique·E J De Waal, L H Rademakers
Aug 1, 1997·Microscopy Research and Technique·R Brelińska, J B Warchol
Jun 1, 1990·Journal of Morphology·R Alvarez
Jan 1, 1986·Cell and Tissue Research·S Khosla, W K Ovalle
Dec 1, 1989·Cell and Tissue Research·R Brelińska
Jan 1, 1985·Cell and Tissue Research·R BrelińskaJ Jaroszewski
Jan 1, 1991·Histochemistry·B Dipasquale, G Tridente
May 1, 1993·Cell and Tissue Research·D Toussaint-DemylleS Haumont
Apr 1, 1991·Cell and Tissue Research·R BrelińskaL Kreja
Feb 1, 1991·Cell and Tissue Research·D Toussaint-DemylleS Haumont
Jul 1, 1990·Cell and Tissue Research·D Toussaint-DemylleS Haumont
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·M Marino, H K Müller-Hermelink
Sep 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·L V BeletskaiaT S Aliev
Nov 2, 1984·Klinische Wochenschrift·H HuberH Stein
Jan 1, 1987·Developmental and Comparative Immunology·B BodeyM Borysenko
Jan 1, 1989·Developmental and Comparative Immunology·J PenningerG Wick
Jul 1, 1995·Developmental and Comparative Immunology·T RiekerG Wick
Sep 1, 1993·Immunology Today·R L BoydP Hugo
Jan 1, 1990·International Journal of Immunopharmacology·T YamashitaM Enomoto
Jan 1, 1991·International Journal of Immunopharmacology·G Sandberg, U Ernström
Oct 1, 1987·Human Immunology·K H Singer, B F Haynes
Jan 1, 1990·Neuroscience·J M LawrenceG Raisman
Jun 1, 1991·Research in Immunology·M HadzijaT L Delovitch
Aug 13, 1998·Developmental and Comparative Immunology·N S Trede, L I Zon
May 8, 1999·Veterinary Immunology and Immunopathology·M MukamotoT Baba
May 18, 2013·Cell Death & Disease·M-f HeX-n Wang
Sep 12, 2008·Nature Reviews. Molecular Cell Biology·Michael Overholtzer, Joan S Brugge
Sep 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Volker BenselerPatrick Bertolino
Nov 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yasushi NakagawaYousuke Takahama

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