Thymic Origin Neuroendocrine Carcinoma Metastasizing to the Orbit in an Otherwise Asymptomatic Patient

Ophthalmic Plastic and Reconstructive Surgery
Kyle D MacLeanBhupendra C K Patel

Abstract

A 39-year-old man without a significant medical history developed headaches, OS swelling, and limited left-sided ocular motility. An ultrasound of the left orbit and head MRI revealed a retro-orbital mass. A partial left anterior orbitotomy with partial resection was performed, and histopathologic examination of the resected tumor portion was suggestive of a neuroendocrine carcinoma. A large, anterior mediastinal mass was found on chest imaging, and the patient was diagnosed with a primary thymic neuroendocrine tumor. To the authors' knowledge, this is the first report of an otherwise healthy patient presenting with the mass effects of a thymic neuroendocrine carcinoma metastasis to the orbital tissues before detection of the primary thymic malignancy.

References

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Nov 21, 2002·The Annals of Thoracic Surgery·Rabih ChaerAlexander S Geha
Dec 20, 2003·Orbit·Lakshmi MaheshJyotirmay Biswas
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May 4, 2012·Orbit·Devron H CharTheodore R Miller
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ÖbergUNKNOWN ESMO Guidelines Working Group

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Citations

Dec 18, 2015·BMC Cancer·Sebastian P HaenFrank Mayer
Sep 18, 2018·Clinical Nuclear Medicine·Yin Jie Chen, Michael D Farwell

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