Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells

Science
Gérard Eberl, Dan R Littman

Abstract

Intestinal intraepithelial T lymphocytes (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been proposed to differentiate from local precursors rather than from thymocytes. We show here that IELs expressing the alphabeta T cell receptor are derived from precursors that express RORgammat, an orphan nuclear hormone receptor detected only in immature CD4+CD8+ thymocytes, fetal lymphoid tissue-inducer (LTi) cells, and LTi-like cells in cryptopatches within the adult intestinal lamina propria. Using cell fate mapping, we found that all intestinal alphabeta T cells are progeny of CD4+CD8+ thymocytes, indicating that the adult intestine is not a significant site for alphabeta T cell development. Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue.

References

Aug 1, 1994·The Journal of Experimental Medicine·B RochaD Guy-Grand
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R E MebiusK Akashi
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H YoshidaS I Nishikawa
Oct 31, 2001·Nature Immunology·A HaydayJ Shires
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiromasa HamadaHiromichi Ishikawa
Mar 1, 2002·Current Opinion in Immunology·Delphine Guy-Grand, Pierre Vassalli
Feb 5, 2003·The Journal of Experimental Medicine·Delphine Guy-GrandPierre Vassalli
Feb 3, 2004·Genesis : the Journal of Genetics and Development·Tim SparwasserGerard Eberl

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Citations

Mar 8, 2011·Inflammatory Bowel Diseases·Gheorghe HundorfeanJonas Mudter
Sep 14, 2013·Seminars in Immunopathology·Jörg Stange, Marc Veldhoen
Apr 6, 2012·Immunologic Research·Alejo ChornyAndrea Cerutti
Mar 16, 2005·Current Opinion in Immunology·Jennifer L Matsuda, Laurent Gapin
Mar 16, 2005·Current Opinion in Immunology·Daniela Finke
Mar 16, 2005·Current Opinion in Immunology·Daniel J PenningtonAdrian C Hayday
Sep 24, 2013·Trends in Immunology·Jianhua YuMichael A Caligiuri
Jan 30, 2013·Immunology and Cell Biology·Stephanie L Sanos, Andreas Diefenbach
May 24, 2013·Nature·Matthew R HepworthGregory F Sonnenberg
Feb 8, 2011·Nature Immunology·Joanne E KonkelWanJun Chen
Dec 17, 2005·Nature Immunology·Adrian Hayday
Mar 22, 2007·Nature Immunology·Estelle BettelliVijay K Kuchroo
Mar 23, 2011·Nature Immunology·Dietmar J Kappes
Jan 24, 2007·Nature Immunology·Adrian C Hayday, Daniel J Pennington
Jul 22, 2005·Nature Reviews. Immunology·Peter J L LaneMi-Yeon Kim
Aug 14, 2010·Nature Reviews. Immunology·Serge A van de Pavert, Reina E Mebius
Jun 18, 2011·Nature Reviews. Immunology·Hilde CheroutreDaniel Mucida
Jan 8, 2013·Nature Reviews. Immunology·Jennifer A WalkerAndrew N J McKenzie
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Maha AyyoubDanila Valmori
Jul 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Taras KreslavskyHarald von Boehmer
Jul 7, 2005·The Journal of Experimental Medicine·Troy A BaldwinKristin A Hogquist
Sep 19, 2007·The Journal of Experimental Medicine·Jun KunisawaHiroshi Kiyono
Apr 30, 2008·The Journal of Experimental Medicine·Taras KreslavskyHarald von Boehmer
May 28, 2008·The Journal of Experimental Medicine·Matthias LochnerGérard Eberl
Oct 14, 2009·The Journal of Experimental Medicine·Takahiro NagatakeHiroshi Kiyono
Feb 10, 2010·The Journal of Experimental Medicine·Naoko Satoh-TakayamaJames P Di Santo
Dec 22, 2010·The Journal of Experimental Medicine·Matthias LochnerGérard Eberl
Mar 21, 2012·The Journal of Experimental Medicine·Marie CherrierGérard Eberl

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