PMID: 6965397Feb 1, 1980Paper

Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen

The Journal of Experimental Medicine
G KelsoeJ Cerny

Abstract

The role of the thymus in the cyclical appearance of the dominant idiotype of the myeloma protein secreted by the TEPC-15 plasmacytoma (T-15)-bearing plaque-forming cells (PFC) and anti-idiotypic cells (i.e., cells with receptors for T-15) in the spleen during a primary response to the phosphorylcholine determinant of Streptococcus pneumoniae, strain R36a (Pn) was studied using normal mice, thymus-deficient nude mice, and thymus gland-grafted nude mice (TG-nude). The nude mice and their phenotypically normal littermates (LM) were backcrossed on the BALB/c genetic background. The kinetics of the anti-Pn PFC response of BALB/c inbred mice, littermates of nude mice, and TG-nude mice were essentially the same. There was an initial peak on day 5-6 followed by a decline to near background, and then a second peak on day 12. In nude mice, the first peak of anti-Pn PFC (day 5) was comparable in magnitude to that of mice with an intact thymus; however, there was no second peak. In contrast to the cellular response measured at the level of PFC, the serum antibody response to Pn (assayed by passive hemagglutination of sheep erythrocytes coated with Pn polysaccharide) was comparable in all groups of mice and did not show a measurable oscill...Continue Reading

References

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Citations

Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R BillettaM Zanetti
Apr 1, 1981·The Journal of Experimental Medicine·K GleasonH Köhler
Jun 1, 1981·The Journal of Experimental Medicine·D A RowleyI Lorbach
Jun 1, 1983·The Journal of Experimental Medicine·M J CaulfieldJ Cerny
Sep 1, 1983·Annales d'immunologie·R Rousseaux-PrévostJ Rousseaux
Mar 21, 2007·Immunological Reviews·Jaroslav StarkAndrew J T George
Feb 1, 1985·Cellular Immunology·M J Caulfield
Jul 1, 1980·Immunology Today·H Ko Hler
Sep 1, 1983·Immunology Today·H M Edinger, C H Heusser
Jan 1, 1982·Journal of Cellular Biochemistry·N R FaridM Nazrul-Islam
May 1, 1986·European Journal of Immunology·H M Etlinger
Jan 1, 1983·Annals of the New York Academy of Sciences·J Cerny, R Cronkhite
Jan 1, 1983·European Journal of Immunology·M N IslamN R Farid
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C L Troisi, F B Hollinger
Jun 1, 1984·Immunological Reviews·M McNamaraH Kohler
Oct 29, 1981·Nature·G M Spurll, F L Owen
Dec 1, 1985·European Journal of Immunology·M ZöllerG Andrighetto
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alan C WhitmorePatrick M Flood
Jan 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·A Cooke
Dec 1, 1980·Microbiological Reviews·L S Rodkey

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