PMID: 6968836Sep 1, 1980Paper

Thymic stimulatory actions of arginine

JPEN. Journal of Parenteral and Enteral Nutrition
A BarbulG Efron

Abstract

Various arginine HCl supplements (0.5-3%), half added to a basal commercial rodent chow (1.8% arginine) and half to the drinking water, were given to 8- to 9-week-old male CBA/J mice for 6 days. Control animals were fed the basal chow and drank tap water. All mice ate and drank ad libitum. Weight gain and food intake were similar in all groups. All arginine supplements increased significantly: thymic weight (average 22%), thymic lymphocyte content (average 45%), and the in vitro reactivity of thymic lymphocytes judged by the incorporation of 3H-leucine into the TCA-precipitable protein fraction in response to stimulation by phytohemagglutinin and concanavalin A. All these thymic effects resulted from the 0.5% arginine hydrochloride supplement; further increases in arginine supplementation did not increase these effects. These data suggest that supplemental arginine may improve host defence mechanisms and thereby may play an important role in the care of severely injured or ill patients, since it is well established that their defense mechanisms are reduced.

References

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Citations

Dec 18, 2012·Archives of Virology·Manu AsthanaRajesh Kumar
Dec 31, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Carmelo Nieves, Bobbi Langkamp-Henken
Nov 13, 2004·The Journal of Nutritional Biochemistry·M D Peck, Y Chang
Dec 5, 2002·Surgery·Juan B Ochoa, Henri R Ford
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Jul 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·K TachibanaY Kishino
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Apr 1, 1997·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R G Barton
Nov 18, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Maria B Witte, Adrian Barbul
Jan 27, 2006·World Journal of Gastroenterology : WJG·Huey-Fang ShangSung-Ling Yeh
Jun 27, 2006·Plastic and Reconstructive Surgery·Meghan Arnold, Adrian Barbul
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Mar 20, 2020·Nutrition & Metabolism·Jian-Sheng Kang
Nov 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·A BarbulE Seifter
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May 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·A BarbulG Efron
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·S J Kirk, A Barbul
Mar 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·A Barbul
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Jun 3, 2021·Journal of Clinical Medicine·Martin D RosenthalFrederick A Moore

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