Thymic stromal lymphopoietin is regulated by the intracellular calcium

Cytokine
Na-Ra HanHyun-Ja Jeong

Abstract

The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development and progression of allergic diseases such as atopic dermatitis. However, it has not been clarified that TSLP would be regulated by intracellular calcium in mast cells yet. To determine it, we blocked intracellular calcium by treatment with calcium chelator, 2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid acetoxymethyl ester (BAPTA-AM) in human mast cell line (HMC-1) cells. BAPTA-AM inhibited the production and mRNA expression of TSLP in phorbol myristate acetate plus A23187- stimulated HMC-1 cells. BAPTA-AM also inhibited the nuclear factor-κB activation, IκBα phosphorylation, receptor interacting protein2 (RIP2) expression, and caspase-1 activation in HMC-1 cells. These results provide evidence that calcium regulates the level of TSLP through RIP2/caspase-1/NF-κB/IκBα signal.

References

Jul 15, 2009·Biochemical and Biophysical Research Communications·Morisada HayakawaShin-ichi Tominaga

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Citations

Dec 4, 2013·Archives of Biochemistry and Biophysics·Na-Ra HanHyun-Ja Jeong
Jan 23, 2016·Archives of Dermatological Research·Na-Ra HanHyung-Min Kim
Apr 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phil-Dong MoonHyun-Ja Jeong
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phil-Dong MoonHyun-Ja Jeong
Feb 11, 2014·Experimental Biology and Medicine·Na-Ra HanHyun-Ja Jeong
Jun 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shi WuJinhao Zeng
Jun 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Na-Ra HanHi-Joon Park
Oct 29, 2021·Immunopharmacology and Immunotoxicology·Jun-Ho YeomHyun-Ja Jeong

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