Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma.

Mucosal Immunology
H HanS F Ziegler

Abstract

Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as the "atopic march." Although the underlying cause of the atopic march remains unknown, recent evidence suggests a role for the cytokine thymic stromal lymphopoietin (TSLP). We have established a mouse model to determine whether TSLP plays a role in this phenomenon, and in this study show that mice exposed to the antigen ovalbumin (OVA) in the skin in the presence of TSLP develop severe airway inflammation when later challenged with the same antigen in the lung. Interestingly, neither TSLP production in the lung nor circulating TSLP is required to aggravate the asthma that was induced upon subsequent antigen challenge. However, CD4 T cells are required in the challenge phase of the response, as was challenge with the sensitizing antigen, demonstrating that the response was antigen specific. This study, which provides a clean mouse model to study human atopic march, indicates that skin-derived TSLP may represent an im...Continue Reading

References

Aug 1, 1992·The American Review of Respiratory Disease·H NakajimaS Yoshida
Jun 1, 1994·American Journal of Respiratory Cell and Molecular Biology·S H GavettM Wills-Karp
Jan 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G G BrusselleH Bluethmann
Jan 1, 1994·Journal of the American Academy of Dermatology·J KayA G Jaron
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M KuligU Wahn
Sep 7, 2000·The Journal of Experimental Medicine·J E SimsR J Paxton
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·L A Beck, D Y Leung
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P A RecheJ F Bazan
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·X ZhangH L Weiner
Jul 12, 2002·The Journal of Allergy and Clinical Immunology·Anne KihlströmGunilla Hedlin
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·Mark E Fortini
May 27, 2003·Nature Reviews. Immunology·Christina A Herrick, Kim Bottomly
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Jonathan M Spergel, Amy S Paller
Dec 2, 2004·Nature Reviews. Immunology·William Cookson
May 10, 2005·Immunology and Allergy Clinics of North America·Eugenia L Hahn, Leonard B Bacharier
Jun 7, 2005·The Journal of Clinical Investigation·Daniel MucidaMaria A Curotto de Lafaille
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sun YingChris Corrigan
Sep 6, 2005·Nature Immunology·Baohua ZhouSteven F Ziegler
Sep 21, 2005·The Journal of Experimental Medicine·Amin Al-ShamiWarren J Leonard
Jun 21, 2006·Nature Immunology·Steven F Ziegler, Yong-Jun Liu
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mei LiPierre Chambon
Apr 3, 2007·Nature Immunology·Alexander AstrakhanDavid J Rawlings
Apr 4, 2008·The New England Journal of Medicine·Thomas Bieber
Aug 23, 2008·Acta Oto-laryngologica·Zhonglin MouDemin Han
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heidi K JessupMichael R Comeau
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark B HeadleySteven F Ziegler
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zhikun ZhangPierre Chambon
Jun 27, 2009·PLoS Biology·Shadmehr DemehriRaphael Kopan
Feb 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan P LarsonSteven F Ziegler
Sep 24, 2010·The Journal of Investigative Dermatology·Malene HvidMette Deleuran

❮ Previous
Next ❯

Citations

Nov 5, 2014·The Journal of Clinical Investigation·Hongwei HanSteven F Ziegler
Oct 24, 2014·Expert Review of Clinical Immunology·Antonella Cianferoni, Jonathan Spergel
Jan 4, 2013·Expert Opinion on Biological Therapy·Sabina Antonela Antoniu
Jan 30, 2016·The Journal of Investigative Dermatology·Jung U ShinKwang Hoon Lee
Dec 30, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I-Jen WangWilfried J J Karmaus
Dec 19, 2013·Drug Discovery Today. Disease Mechanisms·Erin E WestWarren J Leonard
Sep 4, 2012·The Journal of Allergy and Clinical Immunology·Steven F Ziegler
Apr 23, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I-J WangP-C Chen
Jun 19, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jonathan I Silverberg, Eric L Simpson
Apr 14, 2015·Immunity, Inflammation and Disease·Janneke LandheerEdward Knol
Jun 7, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nikki B MarshallStacey E Anderson
May 28, 2015·The Journal of Allergy and Clinical Immunology·Giulia FornasaMaria Rescigno
Jan 21, 2015·Immunology and Cell Biology·Anne-Sophie BergotJames W Wells
May 12, 2015·European Journal of Pharmacology·Christian SchwartzDavid Voehringer
Apr 29, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ha-Jung KimSoo-Jong Hong
Jul 2, 2016·European Journal of Pharmacology·Theodoros KarampitsakosArgyris Tzouvelekis
Oct 25, 2016·Current Allergy and Asthma Reports·Michelle T GrahamKari C Nadeau
Sep 6, 2012·International Archives of Allergy and Immunology·W L WangL F Zhou
Apr 10, 2017·The Journal of Allergy and Clinical Immunology·Maryam HussainMario Noti
Jun 29, 2017·Mucosal Immunology·H HanS F Ziegler
Jun 29, 2017·Immunological Reviews·Masato Kubo
Jun 20, 2017·Parasite Immunology·N Nausch, F Mutapi
Jul 6, 2014·Allergy, Asthma & Immunology Research·Hae-Jin Lee, Seung-Hun Lee
Jan 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Sotaro OchiaiFranca Ronchese
Mar 6, 2018·Immune Network·Hyun Jung ParkSeokmann Hong
Jul 25, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sotaro OchiaiFranca Ronchese
Aug 19, 2016·Current Allergy and Asthma Reports·Naina Gour, Stephane Lajoie
Nov 28, 2018·Allergy, Asthma & Immunology Research·Elizabeth Huiwen Tham, Donald Ym Leung
May 12, 2017·Scientific Reports·Hongwei Han, Steven F Ziegler
Jun 12, 2018·The Journal of Clinical Investigation·Purvi MandeAnn Marshak-Rothstein

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.