Thymic transplantation in pig-to-nonhuman primates for the induction of tolerance across xenogeneic barriers

Methods in Molecular Biology
Kazuhiko Yamada, Joseph Scalea

Abstract

With the advent of knockout pigs for α1,3-galactosyltransferease (GalT-KO, which lack a cell-surface antigen to which humans have preformed antibodies), investigators have extended the survival of life-supporting xenorenal grafts. However, despite these increases, nonhuman primates transplanted with GalT-KO renal grafts are susceptible to anti-donor T-cell responses that are strong or stronger than allogeneic responses. In order to prevent rejection, recipients must be subjected to morbidly high levels of immunosuppression. For these reasons, our laboratory has attempted to develop novel methods of xenogeneic tolerance using vascularized porcine thymic grafts in order to reteach the recipient's immune system to accept the xenogeneic organ as self. These strategies, largely developed by Dr. Kazuhiko Yamada, involve the co-transplantation of a vascularized donor thymus with a kidney. This has been successfully done in two ways. The first method involves the preparation of a composite tissue "thymokidney" and the second utilizes the transplantation of an isolated vascularized thymic lobe. Both strategies involve the transplantation of fully vascularized thymic tissue at the time of xenotransplantation, a fact which is crucial for ...Continue Reading

Citations

Aug 27, 2015·International Journal of Surgery·Laura HigginbothamAndrew B Adams
Aug 21, 2018·Xenotransplantation·David K C CooperDavid C Cleveland
May 11, 2013·Current Opinion in Organ Transplantation·Helena Nunes-Cabaço, Ana E Sousa
Feb 13, 2014·Immunological Reviews·Adam GriesemerMegan Sykes
Jul 12, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Lu LiuLisha Mou

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