PMID: 6163466Feb 26, 1981Paper

Thymidine catabolism and the reutilization of its degradative products in Tetrahymena pyriformis. Metabolism of [2,6-14C2]thymidine and [2-14C]methylmalonic acid

Biochimica Et Biophysica Acta
M A Niemann, J Berech

Abstract

The operation of reductive pyrimidine catabolic and reutilization pathway in Tetrahymena pyriformis was investigated. Consistent with the proposed catabolic interconversions, radioactivity from [2,6-14C2]thymidine was recovered in respired CO2 30 min after its addition to the culture, whereas, consistent with the proposed anabolic interconversions, over 50% of the incorporated label was recovered in cellular macromolecules other than DNA 12 h after its addition. The chromatographic recovery of 14C radioactivity in monosaccharides from [2,6-14C2]thymidine as well as from [2-14C]methylmalonic acid, a key reutilization intermediate in this proposed pathway, further substantiated the operation of the required anabolic interconversions in this organism.

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Citations

May 1, 1993·Antimicrobial Agents and Chemotherapy·S Kaul, K A Dandekar
Sep 1, 1993·Antimicrobial Agents and Chemotherapy·E M CrettonJ P Sommadossi
Aug 15, 1985·Archives of Biochemistry and Biophysics·S P StablerR H Allen
Jan 8, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Lian ZhouRamaswamy A Iyer
Oct 10, 2001·The Journal of Biological Chemistry·Zoran MinicGuy Hervé

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