PMID: 7334381Dec 1, 1981Paper

Thymidine kinase activity is reduced in the developing staggerer cerebellum

Journal of Neurochemistry
A MesserT P Carter

Abstract

In the mouse cerebellar mutant staggerer, thymidine kinase levels do not increase developmentally at ages when the wild-type level is high. Mixing experiments show that this effect is not due to an endogenous inhibitor of the enzyme. Both the Km and the susceptibility of the thymidine kinase to nucleotide inhibitors are unaltered in the mutant animals, suggesting that the enzyme is not induced in the mutant.

References

Jun 15, 1978·The Journal of Comparative Neurology·D M Landis, R L Sidman
May 6, 1977·Brain Research·N YamadaH Nakajima
Jun 4, 1976·Brain Research·C H Yoon
Feb 1, 1972·Journal of Neurochemistry·S YamagamiY Kawakita
Dec 10, 1971·Brain Research·S C Sung
May 21, 1970·Biochimica Et Biophysica Acta·J F Chiu, S C Sung
Jul 1, 1967·Journal of Neuropathology and Experimental Neurology·H S Schutta, L Johnson
Aug 24, 1962·Science·R L SIDMANM M DICKIE

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Citations

Sep 1, 1984·Cellular and Molecular Neurobiology·A MesserP Maskin
May 21, 1993·Brain Research. Developmental Brain Research·G B Grunwald, L M Eisenman
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A MesserG L Snodgrass
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A MesserP Maskin
Sep 9, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A Messer, X Kang
Sep 1, 1984·Journal of Neurogenetics·A Messer, K Hatch
Jul 1, 1990·Journal of Neurochemistry·A MesserB Eisenberg
Jan 1, 1987·Journal of Neuroscience Research·J S BruggeA Messer

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