Abstract
Thymidine phosphorylase (TP) has chemotactic activity in endothelial cells in vitro and angiogenic activity in vivo. However, the clinical significance of TP and cooperative roles of TP with other angiogenic factors have remained unclear in nonsmall cell lung carcinoma (NSCLC). The authors stained for TP, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in 132 tumors from patients with Stage I NSCLC. They compared TP, VEGF, and bFGF expression levels with microvessel counts (MVCs), macrophage counts, mast cell counts, and clinical outcomes of patients with Stage I NSCLC. In adenocarcinoma samples, only stromal cell-TP expression and tumor cell-VEGF expression were associated with MVCs and mast cell counts but not with macrophage counts. In squamous cell carcinoma samples, there were no significant associations of the expression of any examined angiogenic factors with MVCs, mast cell counts, or macrophage counts. More importantly, only among patients with Stage I adenocarcinoma of the lung did patients in the stromal cell-TP positive tumor group and in the tumor cell-VEGF positive tumor group have a significantly worse prognosis compared with patients in the stromal cell-TP negative tumor grou...Continue Reading
References
Jun 1, 1977·Journal of the National Cancer Institute·J L PaulyM J Germain
Apr 23, 1992·Nature·T FurukawaY Yamada
May 15, 1992·Biochemical and Biophysical Research Communications·K UsukiC H Heldin
Apr 13, 1989·Nature·F IshikawaC H Heldin
Mar 1, 1994·Journal of Leukocyte Biology·C SunderkötterC Sorg
Mar 17, 1994·Nature·M HaraguchiY Yamada
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·A MoghaddamR Bicknell
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·A YuanK T Luh
Feb 1, 1996·British Journal of Cancer·S B FoxA L Harris
Apr 1, 1996·British Journal of Cancer·K MaedaM Sowa
Aug 21, 1996·Journal of the National Cancer Institute·Y TakebayashiT Aikou
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y TakebayashiT Aikou
Aug 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I TakanamiS Kodaira
Jan 1, 1997·British Journal of Cancer·M I KoukourakisA L Harris
Jul 4, 1998·British Journal of Cancer·M I KoukourakisA L Harris
Jul 4, 1998·Cancer Letters·M MatsumuraN Tanigawa
Oct 10, 1998·International Journal of Cancer. Journal International Du Cancer·S DiasF Balkwill
Jul 22, 1999·Human Pathology·F GuddoG Bonsignore
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·N ShijuboS Abe
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M C IgnatescuI M Lang
Feb 25, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G CoxK J O'Byrne
Apr 26, 2000·British Journal of Cancer·K J O'ByrneA L Harris
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·H HamadaL S Newman
Jun 30, 2000·Japanese Journal of Cancer Research : Gann·J MoriN Tanaka
Jul 8, 2000·The European Respiratory Journal·A ImadaS Abe
Jul 13, 2000·The Annals of Thoracic Surgery·M TomitaT Onitsuka
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·D RibattiF Dammacco
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Citations
Dec 23, 2003·Immunology Letters·Evan P AdlerRobert A Kurt
Apr 15, 2004·Immunology Letters·Lilach Goldberg-BittmanAdit Ben-Baruch
Jul 16, 2003·Cancer Letters·Takanori SonodaHitoo Nakano
Aug 12, 2004·Radiology·Chin A YiSeonwoo Kim
Apr 26, 2003·Radiology·Kiminori FujimotoNaofumi Hayabuchi
Jun 4, 2013·Immunotherapy·Melissa A HendersonMichael H Kershaw
Jan 1, 2009·Immunotherapy·Trina J Stewart, Mark J Smyth
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Roy M BremnesLill-Tove Busund
Mar 26, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tom DonnemRoy M Bremnes
Oct 1, 2011·Clinical Lung Cancer·Thomas J Semrad, Philip C Mack
Oct 19, 2010·International Journal of Radiation Oncology, Biology, Physics·Dirk RadesFrank Noack
Oct 28, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Niels ReinmuthRolf M Mesters
May 13, 2009·Medicinal Research Reviews·Annelies BronckaersSandra Liekens
Jun 19, 2007·Biochemical Pharmacology·Sandra LiekensJan Balzarini
Apr 25, 2015·The EPMA Journal·Godfrey GrechDominic M Desiderio
May 22, 2010·The American Journal of Pathology·Hiroaki ShimoyamadaHitoshi Kitamura
Mar 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Chun-Long ZhengJia-Jun Du
Jan 30, 2016·PloS One·Mingming HuBaolan Li
Aug 24, 2005·Cancer·Hiroshi KojimaNoriyuki Sato
Mar 31, 2006·International Journal of Cancer. Journal International Du Cancer·Hidekazu KuramochiPeter V Danenberg
Mar 25, 2006·International Journal of Cancer. Journal International Du Cancer·Niels ReinmuthMichael Thomas
Jan 23, 2003·Microscopy Research and Technique·Noriharu ShijuboNoriyuki Sato
Jun 7, 2018·Oncotarget·Ross A SooRichie Soong
Dec 14, 2018·Molecular and Clinical Oncology·Naoya HimuroMitsutaka Kadokura
Nov 24, 2016·BMC Cancer·J RappJ E Pongracz
Dec 1, 2005·British Journal of Cancer·P KabuubiC M L West
Dec 3, 2005·Leukemia & Lymphoma·Tryfonia Mainou-FowlerKatrina M Wood
Jan 7, 2020·Oncotarget·Stephanie TuminelloEmanuela Taioli
Nov 17, 2005·Cancer Research·Erica L JacksonTyler Jacks
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil SinghalSteven M Albelda