Thymidine phosphorylase promotes metastasis and serves as a marker of poor prognosis in hepatocellular carcinoma

Laboratory Investigation; a Journal of Technical Methods and Pathology
Qiang ZhangCheng Yang

Abstract

Hepatocellular carcinoma (HCC) ranks as one of the most common and lethal malignancies worldwide. A better understanding of the mechanism responsible for HCC metastasis will be helpful for the treatment of HCC patients. Thymidine phosphorylase (TP), a key enzyme that catalyzes the conversion of thymidine to thymine and deoxyribose-1-phosphate, was demonstrated to promote the invasion and metastasis of HCC in our study. Clinical retrospective analysis revealed that metastatic HCC tumor tissues have higher TP expression, and TP expression was significantly correlated with matrix metalloproteinase (MMP) 2 and 9 expression. Survival analysis revealed that TP expression was negatively correlated with the prognosis of HCC patients. Moreover, in vitro cell experiments confirmed that TP could promote the migration and invasion of HCC cells. In addition, MMP2 and MMP9 were activated by TP overexpression. Overall, this study suggests that TP promotes metastasis and may serve as a marker of poor prognosis in HCC. Thus, TP is a potential target for the treatment of HCC.

References

Nov 19, 1985·Biochemistry·M H IltzschS Cha
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y TakebayashiT Aikou
Apr 29, 2006·International Journal of Cancer. Journal International Du Cancer·Yuichi NakajimaShin-ichi Akiyama
Feb 12, 2008·The American Journal of Medicine·Richard Todd StravitzRobert A Fisher
May 13, 2009·Medicinal Research Reviews·Annelies BronckaersSandra Liekens
Sep 2, 2010·Journal of the American Chemical Society·Phillip A SchwartzVern L Schramm
Feb 7, 2012·The Journal of Clinical Investigation·Naoe TairaKiyotsugu Yoshida
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Feb 1, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·J Michael WellsJ Edwin Blalock
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
May 24, 2016·Journal of Hepatology·Gianluigi GiannelliWolfgang Mikulits
Jul 5, 2016·Frontiers in Cell and Developmental Biology·Roser BuscàPhilippe Lenormand

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Citations

Feb 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ning ZhengJichuang Wang

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