Abstract
Hepatocellular carcinoma (HCC) ranks as one of the most common and lethal malignancies worldwide. A better understanding of the mechanism responsible for HCC metastasis will be helpful for the treatment of HCC patients. Thymidine phosphorylase (TP), a key enzyme that catalyzes the conversion of thymidine to thymine and deoxyribose-1-phosphate, was demonstrated to promote the invasion and metastasis of HCC in our study. Clinical retrospective analysis revealed that metastatic HCC tumor tissues have higher TP expression, and TP expression was significantly correlated with matrix metalloproteinase (MMP) 2 and 9 expression. Survival analysis revealed that TP expression was negatively correlated with the prognosis of HCC patients. Moreover, in vitro cell experiments confirmed that TP could promote the migration and invasion of HCC cells. In addition, MMP2 and MMP9 were activated by TP overexpression. Overall, this study suggests that TP promotes metastasis and may serve as a marker of poor prognosis in HCC. Thus, TP is a potential target for the treatment of HCC.
References
Nov 19, 1985·Biochemistry·M H IltzschS Cha
Aug 21, 1996·Journal of the National Cancer Institute·Y TakebayashiT Aikou
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y TakebayashiT Aikou
Jul 11, 1997·Science·G GiannelliV Quaranta
Aug 29, 1998·Journal of Hepatology·A YamamotoN Nagasue
Apr 29, 2006·International Journal of Cancer. Journal International Du Cancer·Yuichi NakajimaShin-ichi Akiyama
Feb 12, 2008·The American Journal of Medicine·Richard Todd StravitzRobert A Fisher
Oct 17, 2008·Molecular Cancer Research : MCR·Eun Jeong YuHei-Cheul Jeung
Nov 22, 2008·Circulation Research·Giordano PulaManuel Mayr
May 13, 2009·Medicinal Research Reviews·Annelies BronckaersSandra Liekens
Sep 2, 2010·Journal of the American Chemical Society·Phillip A SchwartzVern L Schramm
Nov 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ya-Li JiaXue-Tao Pei
Dec 20, 2011·Cancer Letters·Tomohiko MiyataniMitsuo Shimada
Feb 7, 2012·The Journal of Clinical Investigation·Naoe TairaKiyotsugu Yoshida
Sep 14, 2012·Blood·Sabina AdhikaryDoina Ganea
Apr 4, 2014·Chinese Journal of Cancer·Dana LoomisGuosheng Chen
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Feb 1, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·J Michael WellsJ Edwin Blalock
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jan 7, 2016·Oncotarget·Manuela Terranova-BarberioElena Di Gennaro
Mar 17, 2016·Oncotarget·Chia-Ming YehShun-Fa Yang
Mar 18, 2016·Cancer Discovery·Miles A MillerDouglas A Lauffenburger
May 24, 2016·Journal of Hepatology·Gianluigi GiannelliWolfgang Mikulits
Jul 5, 2016·Frontiers in Cell and Developmental Biology·Roser BuscàPhilippe Lenormand
Sep 1, 2016·Oncotarget·Hyein JeonKi Won Lee
Sep 16, 2016·Scientific Reports·Zhaowen WangZhihai Peng
Citations
Aug 21, 2020·Journal of Biomolecular Structure & Dynamics·Sadia NazNadia Riaz
Jan 25, 2019·Cell Death & Disease·Qiang ZhangCheng Yang
Jan 16, 2019·Molecular Cancer Therapeutics·Huijuan LiuCheng Yang
Feb 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ning ZhengJichuang Wang