Thymidine phosphorylase/platelet-derived endothelial cell growth factor (PD-ECGF) associated with prognosis in renal cell carcinoma

Urological Research
K SuzukiA Tokue

Abstract

We investigated the correlation between thymidine phosphorylase (TP)/platelet-derived endothelial cell growth factor (PD-ECGF) expression, angiogenesis, and prognosis in renal cell carcinoma (RCC) patients. We prepared paraffin block specimens from 56 postradical nephrectomy RCC patients. The preparations were immunohistochemically stained using anti-CD34 antibody and anti-TP antibody. Angiogenic findings were evaluated based on both microvessel density (MVD) and renal arteriography findings as classified by Roosen et al. TP expression showed heterogeneity in 56 patients: 11 (19.6%) were negative, 28 (50.0%) weak, and 17 (30.4%) positive. There was no correlation between TP expression, MVD, and renal arteriography. There was no TP expression in chromophobe types. Univariate analysis showed a significant correlation between survival and TP expression, patient age, tumor infiltration type, pathologic T- and N-stages, venous involvement, distant metastasis, and tumor grade. There was no correlation between survival and MVD or renal arteriography. Multivariate analysis showed a significant correlation between survival and pathologic T-stage, distant metastasis, tumor infiltration type, and TP expression. TP expression in RCC may be...Continue Reading

Citations

Jul 3, 2009·International Urology and Nephrology·Peeter Padrik, Helgi Saar
Mar 11, 2006·Nature Clinical Practice. Urology·Philip J S Charlesworth, Adrian L Harris
Mar 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Debendranath BanerjeeR S K Chaganti
May 1, 2002·Current Opinion in Oncology·Paul Godley, Steven W Kim
Apr 2, 2013·Journal of Clinical Pathology·Naoki KanomataTakuya Moriya
Apr 29, 2008·Cancer Treatment Reviews·D FurnissUNKNOWN National Cancer Research Institute Renal Clinical Studies Group
Mar 1, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazumi SuzukiAkihiko Tokue
May 13, 2009·Medicinal Research Reviews·Annelies BronckaersSandra Liekens
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hai-Lun ZhanDe-Juan Wang
Apr 3, 2002·Japanese Journal of Cancer Research : Gann·Hidetoshi KinsuiHaruo Ito
Nov 7, 2008·Journal of Experimental & Clinical Cancer Research : CR·Elzbieta Miszczak-ZaborskaJacek Bartkowiak
Oct 29, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Tetsuya ImaoMikio Namiki
Jul 25, 2006·Japanese Journal of Clinical Oncology·Tatsuya TakayamaSeiichiro Ozono

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