PMID: 8611421Apr 1, 1996Paper

Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma

British Journal of Cancer
K MaedaM Sowa

Abstract

It is known that angiogenesis plays an important role in the growth and metastasis of solid tumours. Several angiogenic factors have been identified and platelet-derived endothelial cell growth factor (PD-ECGF) is thought to be one such factor. Recently, it was reported that thymidine phosphorylase (dThdPase) is identical to PD-ECGF. Using immunohistochemical staining with an anti-dThdPase antibody, we investigated the correlation between dThdPase expression and the microvessel density in 120 gastric carcinomas. The microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in dThdPase-positive tumours than in dThdPase-negative tumors. There was a significant correlation between dThdPase expression and the increment of microvessel density. Moreover, regarding distant organ metastasis, the frequency of hepatic metastasis was significantly higher (P < 0.01) in patients with dThdPase-positive tumours than in those with dThdPase-negative tumors. In summary, it was suggested that dThdPase expression is closely associated with the promotion of angiogenesis and hepatic metastasis in gastric carcinoma.

Citations

Jun 1, 2000·Scandinavian Journal of Gastroenterology·M Ohi, C Miki
Feb 2, 2002·American Journal of Clinical Oncology·A GiatromanolakiC Simopoulos
Jun 13, 2002·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N KoideJ Amano
May 31, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masanori TerashimaMitsukazu Gotoh
May 17, 2007·British Journal of Cancer·E SatoT Tamaya
Sep 30, 2006·Chemotherapy·Satoshi IshizoneShinichi Miyagawa
Dec 19, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Yasuhiko Kitadai
Apr 7, 2010·Journal of Oncology·Yasuhiko Kitadai
Mar 26, 2015·Brain : a Journal of Neurology·Candice ChapoulyGareth R John
Apr 17, 1999·British Journal of Cancer·K HataM Fukumoto
Jun 8, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·N KawataY Takimoto
Apr 3, 2002·International Journal of Surgical Pathology·Shin-ichi AishimaMasazumi Tsuneyoshi
Dec 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T KonoS Kasai
Jun 11, 2005·European Journal of Gastroenterology & Hepatology·Zhang Ying-TaoWang Yi-Li
Nov 7, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N KoideJ Amano
Jul 11, 2018·World Journal of Gastrointestinal Oncology·Dai ShimizuYasuhiro Kodera
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R T PoonJ Wong
Jan 10, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Tianshu ZhangJun Amano
Aug 9, 2002·Annals of Surgical Oncology·Akihiko TakedaLee M Ellis
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·K MaedaM Sowa
Apr 3, 2002·Japanese Journal of Cancer Research : Gann·Hidetoshi KinsuiHaruo Ito
Nov 7, 2008·Journal of Experimental & Clinical Cancer Research : CR·Elzbieta Miszczak-ZaborskaJacek Bartkowiak

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