Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in tumor tissues and the efficacy of 5-fluorouracil in patients with non-small-cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Yasushi ShintaniHikaru Matsuda

Abstract

We examined 116 stage I-IIIA non-small-cell lung cancer (NSCLC) patients for intra-tumoral expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) using TaqMan reverse transcription polymerase chain reaction (RT-PCR) assay to clarify the correlation between gene expression and the efficacy of 5-fluorouracil (5-FU) in patients with NSCLC. Patients who were administered 5-FU alone after surgery comprised the 5-FU group (n = 30), and those who underwent only surgery comprised the control group (n = 86). When dichotomized at the mean TS and DPD mRNA level, patients with low-DPD tumors who were administered 5-FU had a significantly better prognosis than those who did not receive adjuvant treatment (p = 0.041). In addition, in the 5-FU group, 10 patients with both low-TS and low-DPD tumors have not had any relapse, whereas 8 of the 20 patients with either high-TS or high-DPD tumors developed distant metastasis after surgery. Based on these results, the quantitation of TS and DPD mRNA levels may predict the efficacy of 5-FU after surgery for patient with NSCLC.

References

Dec 23, 1977·Biochimica Et Biophysica Acta·P V Danenberg
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A BeckG Milano
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H J LenzL Leichman
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H WadaT Teramatsu
Oct 23, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C G LeichmanP V Danenberg
Oct 7, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F TanakaH Wada
Nov 21, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M HigashiyamaH Kobayashi
Dec 21, 2002·International Journal of Clinical Oncology·Tokujiro YanoSadanori Takeo
Dec 24, 2002·Japanese Journal of Cancer Research : Gann·Hisataka FujiwaraMasakazu Fukushima
Mar 18, 2003·International Journal of Cancer. Journal International Du Cancer·Yasushi ShintaniHikaru Matsuda

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Citations

Aug 1, 2013·Archives of Pathology & Laboratory Medicine·Kirk D JonesKelly J Butnor
Mar 28, 2006·Future Oncology·Cheng-Long HuangMoritoshi Kinoshita
Nov 30, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masayuki TakedaKazuhiko Nakagawa
Jul 28, 2010·Expert Review of Respiratory Medicine·Sandra C TomaszekDennis A Wigle
Mar 2, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Fabian MairingerHelmut Popper
May 5, 2010·Clinical Lung Cancer·Mark A Socinski
Apr 14, 2009·Clinical Lung Cancer·Giorgio V ScagliottiSilvia Novello
Mar 31, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·V SurmontR J van Klaveren
Apr 15, 2008·Vascular Pharmacology·Vummidi Giridhar PremkumarPanchanatham Sachdanandam
Jan 17, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T AndoY Fujii
Oct 1, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaaki NishiYoshimi Bando
May 28, 2011·International Journal of Cancer. Journal International Du Cancer·Paolo CeppiGiorgio V Scagliotti
Jul 5, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tetsuya OguriRyuzo Ueda
Mar 22, 2014·Molecular and Clinical Oncology·Keita KudoMakoto Nishio

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