Abstract
Thymidylate synthase (TS) is a crucial enzyme in folate metabolism and plays a vital role in DNA synthesis and repair. The most common polymorphism in TS is a unique double (2R) or triple (3R) 28-bp tandem repeat sequence in the enhancer region of the TS gene (TSER). This genetic variation in TSER has been widely investigated and has been implicated as a risk factor for the development of various cancers, including acute lymphoblastic leukemia. It has also been found to influence sensitivity to anti-cancer drugs, such as methotrexate. We evaluated this polymorphism in acute lymphoblastic leukemia patients in the Kashmir population. In order to determine whether a double (2R2R) versus a triple (3R3R) 28-bp tandem repeat in the TSER modulates risk for acute lymphoblastic leukemia, 72 acute lymphoblastic leukemia cases and 144 age and gender matched, unrelated healthy individuals from the Kashmir region of India were evaluated for this polymorphism by PCR and direct sequencing. We found the frequency of the TS 2R allele to be 32.6 and 26.0%, in cases and controls, respectively. The TS 2R/2R genotype was found to be present in 15.27% of the cases and 9.72% of the controls, the 2R/3R variant in 34.72% of the cases and 32.63% of the ...Continue Reading
References
Dec 23, 1977·Biochimica Et Biophysica Acta·P V Danenberg
Sep 1, 1976·Nucleic Acids Research·N Blin, D W Stafford
Jun 1, 1995·Cell Structure and Function·N HorieK Takeishi
Jul 18, 1997·The Journal of Biological Chemistry·N Horie, K Takeishi
Mar 27, 2002·The Pharmacogenomics Journal·S T PullarkatH J Lenz
May 3, 2002·Blood·Christine F SkibolaGareth J Morgan
Aug 30, 2002·British Journal of Haematology·Ray A CartwrightAnthony V Moorman
Sep 6, 2003·Blood·Maja KrajinovicDaniel Sinnett
Jul 31, 2004·Carcinogenesis·Jianhui ZhangShijie Wang
Nov 13, 2004·The Journal of Nutritional Biochemistry·Y I Kim
Mar 31, 2007·Leukemia Research·Elisa GiovannettiJacqueline Cloos
Apr 25, 2007·Leukemia & Lymphoma·Bohanec Grabar PetraDolzan Vita
Jul 28, 2007·Leukemia Research·Carmen S P LimaFernando F Costa
Mar 25, 2008·Lancet·Ching-Hon PuiA Thomas Look
Nov 8, 2008·Pediatric Blood & Cancer·Nikolaos V KarathanasisMaria Kalmanti
Nov 21, 2008·Blood·Robert de JongeRob Pieters
Sep 25, 2009·British Journal of Haematology·Ilan J N KoppenGertjan J L Kaspers
Jan 27, 2010·Blood·Tracy J LightfootUNKNOWN United Kingdom Childhood Cancer Study
Citations
Aug 13, 2013·Pharmacogenomics·Aurea LimaRui Medeiros
Mar 20, 2014·BMC Cancer·Lei WangHaiquan Chen
Oct 5, 2013·Gene·Fakhira Hassan NazkiBashir Ahmad Ganaie
Sep 19, 2014·PloS One·Laura W GoffA Craig Lockhart
Feb 17, 2017·Medicine·Zhaohua QiaoLi Ruan
Mar 4, 2018·Journal of Clinical Pharmacy and Therapeutics·S-M WangD Yan
May 1, 2016·Personalized Medicine·Yue ZhaoXiang Chen
Jun 8, 2017·Genes & Nutrition·Catia Daniela CantarellaSabrina Tosi
Mar 20, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Nageswara Rao DunnaSatti Vishnupriya
Aug 1, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Wan-Liang GuoJian Wang
Nov 15, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth MilneBruce K Armstrong
Feb 21, 2021·The Pharmacogenomics Journal·Moh'd KhushmanAjay P Singh