PMID: 6968598Oct 1, 1980Paper

Thymocyte receptors reacting with erythrocytes and the Fc-fragment of IgG

Biulleten' eksperimental'noĭ biologii i meditsiny
I A BezvershenkoA L Sinel'nikova

Abstract

A receptor structure that has an affinity to autologous and xenogenic red blood cells was isolated from rat thymocytes by means of adsorption on immobilized rabbit IgG. This structure restores the rosette formation on addition to thymocytes deprived of their receptors for autologous red blood cells and having no capacity for rosette formation. The substance affinity for red blood cells and rabbit IgG is caused by its glycoprotein with a molecular weight of 12 000 daltons, that displays the properties inherent in thymocyte Fc-receptors. The purified glycoprotein can also restore rosette formation in thymocytes deprived of their receptors for autologous red blood cells. A suggestion is made that at least one of Fc-receptors of the T-lymphocyte membrane is capable of reacting with red blood cells.

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