PMID: 6982474Sep 1, 1982Paper

Thymocyte rosettes: multicellular complexes of lymphocytes and bone marrow-derived stromal cells in the mouse thymus

Proceedings of the National Academy of Sciences of the United States of America
B A KyewskiH S Kaplan

Abstract

We describe the isolation and purification of multicellular complexes composed of lymphocytes and bone marrow-derived stromal cells ("thymocyte rosettes") from the mouse thymus. These rosettes are the structural in vitro correlate of in vivo associations between lymphoblasts and I-A/E negative macrophages or medullary I-A/E positive dendritic-like cells. Both types of rosettes are preformed in vivo. The rosette-associated thymocytes display a surface antigen phenotype typical of immature thymocytes. In radiation chimeras, replacement of host thymocytes by injected bone marrow cells follows a regular pattern: donor type T cells appear first at day 11 as clusters around I-A negative macrophages and approximately 2 days later as similar clusters associated with either I-A positive cortical epithelial cells or I-A positive medullary dendritic cells. These data suggest (a) a defined sequence of lymphostromal interactions during intrathymic maturation and (b) a rapid proliferation of thymocytes after interaction with stromal cells.

References

Sep 1, 1972·The Journal of Experimental Medicine·E Raviola, M J Karnovsky
Feb 1, 1973·The Journal of Experimental Medicine·I L Weissman
Jan 1, 1980·Immunological Reviews·R M Steinman, M C Nussenzweig
Jun 1, 1981·The Journal of Experimental Medicine·A N Barclay, G Mayrhofer
Jan 1, 1963·The American Journal of Anatomy·S L CLARK
Jan 1, 1971·European Journal of Immunology·N K Jerne

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Citations

Aug 1, 1997·Microscopy Research and Technique·R Brelińska, J B Warchol
Aug 1, 1997·Microscopy Research and Technique·M LafontaineS Montplaisir
Feb 1, 1991·Cell and Tissue Research·D Toussaint-DemylleS Haumont
Nov 1, 1985·Developmental Biology·E Rothenberg, J P Lugo
Jan 1, 1986·Comparative Immunology, Microbiology and Infectious Diseases·G MathéJ L Misset
May 1, 1994·Immunology Letters·K WinkelK Shortman
Sep 1, 1993·Immunology Today·R L BoydP Hugo
Feb 1, 1987·Human Immunology·O Acuto, L M Larocca
Oct 1, 1987·Human Immunology·K H Singer, B F Haynes
Jan 1, 1985·International Journal of Radiation Oncology, Biology, Physics·I L Weissman
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K H SingerB F Haynes
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P M Cardarelli, M D Pierschbacher
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M CrossR Renkawitz
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·N PlattS Gordon
Feb 1, 1984·The Journal of Experimental Medicine·P J FinkI L Weissman
Jun 1, 1994·The Journal of Experimental Medicine·M S VacchioJ D Ashwell
Jun 1, 1996·The Journal of Experimental Medicine·S OehenS M Hedrick
Feb 7, 2001·The Journal of Experimental Medicine·D L FossI Goldschneider
Feb 5, 2003·The Journal of Experimental Medicine·Mirja Hommel, Bruno Kyewski
Feb 27, 2004·Immunology and Cell Biology·Mirja Hommel
Jul 8, 2000·Archives of Histology and Cytology·Y ArudchelvanF Shinozaki
Oct 1, 1988·Immunology Today·P Marrack, J Kappler
Jul 1, 1984·The American Journal of Anatomy·N M Le DouarinP D Oliver
Jul 30, 2010·Journal of Applied Microbiology·L SzulcM G Niemialtowski
Apr 1, 1991·Cellular Immunology·M PezzanoJ Guyden
Feb 1, 1991·Immunology Today·R L Boyd, P Hugo

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