PMID: 15374121Mar 1, 1997Paper

Thymocytopoiesis in aging: the bone marrow-thymus axis

Archives of Gerontology and Geriatrics
A Globerson

Abstract

Manifestations of aging in the mature T lymphocyte compartment have been attributed, to a major extent, to effects of the involuted thymus, at the thymic microenvironment level. However, since generation of T lymphocytes starts from hemopoietic stem cells that settle in the thymus and differentiate there, aging effects on the stem cells, and as a consequence, on the bone marrow (BM)-thymus axis, may also have an impact on patterns of thymocytopoiesis and on age-related thymus remodeling. This communication reviews our studies designed to determine whether BM cells manifest any aging effects that become overt in the resulting thymocytes. The experiments were performed by seeding of BM cells onto lymphoid-depleted fetal thymus (FT) explants, to enable distinguishing between processes that occur in the BM and those that are caused by the aging thymic microenvironment. The data show changes in the developmental potential of BM-derived cells, as reflected from the kinetics of cell cycle and intermediate steps from stem cell settling in the thymus to an early stage at the transition from CD4(-)CD8(-), double negative (DN), to CD4(+)CD8(+), double positive (DP) thymocytes. In addition, we have demonstrated that these early development...Continue Reading

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Citations

Jul 5, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kathleen Jentsch-UllrichAstrid Franke
Feb 13, 2001·Mechanisms of Ageing and Development·R B Effros
Nov 9, 2000·Immunology Today·A Globerson, R B Effros
Aug 7, 2003·Experimental Hematology·Gary Van Zant, Ying Liang
Feb 13, 2001·Experimental Gerontology·A Globerson
Jun 11, 1999·Experimental Gerontology·A Globerson
Jul 18, 2006·Aging Cell·Alexandra Stolzing, Andrew Scutt
Nov 10, 2013·AIDS Research and Therapy·Erick M BosireVincent Okoth
Nov 25, 2003·Microscopy Research and Technique·Olivia García-SuárezGiovanni Germanà
Mar 29, 2002·Nature Immunology·Hartmut Geiger, Gary Van Zant

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