Thymoma associated with pure red cell aplasia, immunoglobulin deficiency and an inhibitor of antigen-induced lymphocyte transformation.

British Journal of Haematology
C G GearyJ Zervas

Abstract

A case of thymoma associated with pure red cell aplasia and hypogammaglobulinaemia is described in which the anaemia was of abrupt onset, following removal of the tumour. Tests of immunological function showed abnormalities of both humoral and cellular immunity. The patient was found to have a serum inhibitor of antigen-induced lymphocyte transformation which disappeared after immunosuppressive therapy at the same time that erythroblasts reappeared in the marrow. It is suggested that the triad of thymoma, pure red cell aplasia and immunoglobulin deficiency are manifestations of 'pluripotent' stem cell failure; in this case the inhibitor of lymphocyte transformation may have been related to the factor which also inhibited red cell maturation.

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Citations

Jan 1, 1982·The Japanese Journal of Surgery·K ShibataH Ichimura
Jun 10, 1998·Journal of the Neurological Sciences·S Schmidt, F Padberg
Aug 24, 2013·The New England Journal of Medicine·Margaret SetonAbner Louissaint
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