Thymomas with prominent signet ring cell-like features: a clinicopathologic and immunohistochemical study of 10 cases

Human Pathology
Annikka Weissferdt, Cesar A Moran

Abstract

Ten cases of an unusual growth pattern of thymomas are presented. The patients were 8 men and 2 women between the ages of 43 and 62 years. Clinically, 6 patients presented with symptoms of chest pain, cough, and shortness of breath, whereas 4 patients were asymptomatic. Surgical resection of the mediastinal mass was performed in all patients obtaining tumors that varied in size from 4 to 11 cm in greatest dimension. Grossly, the tumors were described as round and well defined, which, at cut surface, showed a firm consistency with a slight lobulated appearance. Areas of necrosis and/or hemorrhage were not present. Histologically, all the tumors showed similar growth pattern characterized by the presence of cells arranged in small cords dissecting fibroconnective tissue and, in some areas, resembling "signet ring" cells. Mitotic activity was not present. Using the Masaoka staging system, 6 cases were in stage I, and 4 cases were in stage II. Histochemical stains for periodic-acid Schiff stain with diastase and mucicarmine were negative for intracytoplasmic mucin. Immunohistochemical studies for CAM5.2 and cytokeratin 5/6 showed a strong positive reaction, whereas thyroid transcription factor 1, epithelial membrane antigen, calret...Continue Reading

References

Jun 1, 1993·The American Journal of Surgical Pathology·C A Moran, M N Koss
Jun 17, 2004·American Journal of Clinical Pathology·Cesar A Moran, Saul Suster
Sep 21, 2010·The American Journal of Surgical Pathology·Annikka WeissferdtCesar A Moran
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bryan N Coffing, Megan S Lim

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Citations

Jul 3, 2016·American Journal of Clinical Pathology·Annikka WeissferdtCesar A Moran
Sep 28, 2018·International Journal of Surgical Pathology·Richard Benedict Supan RoxasMauro Papotti
Jun 5, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Annikka Weissferdt, Cesar A Moran
Jun 21, 2021·Seminars in Diagnostic Pathology·Diana M Oramas, Cesar A Moran

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