Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA

American Journal of Physiology. Endocrinology and Metabolism
Joshua P GrayEmma A Heart

Abstract

Thymoquinone (2-isopropyl-5-methylbenzo-1,4-quinone) is a major bioactive component of Nigella sativa, a plant used in traditional medicine to treat a variety of symptoms, including elevated blood glucose levels in type 2 diabetic patients. Normalization of elevated blood glucose depends on both glucose disposal by peripheral tissues and glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. We employed clonal β-cells and rodent islets to investigate the effects of thymoquinone (TQ) and Nigella sativa extracts (NSEs) on GSIS and cataplerotic metabolic pathways implicated in the regulation of GSIS. TQ and NSE regulated NAD(P)H/NAD(P)(+) ratios via a quinone-dependent redox cycling mechanism. TQ content was positively correlated with the degree of redox cycling activity of NSE extracts, suggesting that TQ is a major component engaged in mediating NSE-dependent redox cycling. Both acute and chronic exposure to TQ and NSE enhanced GSIS and were associated with the ability of TQ and NSE to increase the ATP/ADP ratio. Furthermore, TQ ameliorated the impairment of GSIS following chronic exposure of β-cells to glucose overload. This protective action was associated with the TQ-dependent normalization of chronic accumulati...Continue Reading

References

Jun 1, 1991·Bioscience Reports·M J MacDonald
Jan 1, 1986·Diabetes/metabolism Reviews·M D Meglasson, F M Matschinsky
Nov 1, 1987·Chemistry and Physics of Lipids·M Comporti
Jan 1, 1970·Vitamins and Hormones·E C SlaterW Boers
Jul 25, 1997·The Journal of Biological Chemistry·F SchuitM Prentki
Mar 22, 2000·Chemical Research in Toxicology·J L BoltonT J Monks
Sep 1, 2000·Seminars in Cell & Developmental Biology·J T DeeneyB E Corkey
Feb 26, 2003·The Journal of Biological Chemistry·Haiyan WangClaes B Wollheim
May 2, 2003·Phytotherapy Research : PTR·B H Ali, Gerald Blunden
Oct 16, 2004·Fundamental & Clinical Pharmacology·Halima RchidYves Sauvaire
Nov 16, 2004·Molecular and Cellular Endocrinology·Hans E Hohmeier, Christopher B Newgard
Jul 12, 2005·Human Genomics·Vasilis Vasiliou, Daniel W Nebert
Aug 11, 2005·Journal of Cell Science·Haiyan WangClaes B Wollheim
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patrick E MacDonaldPatrik Rorsman
Apr 4, 2007·Cell Metabolism·Richard G KibbeyGerald I Shulman
May 19, 2007·Antioxidants & Redox Signaling·Yasuo Ido
Nov 18, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M KhaderP M Eckl
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Mar 19, 2009·American Journal of Physiology. Endocrinology and Metabolism·Emma HeartPeter J S Smith
Apr 17, 2009·Canadian Journal of Physiology and Pharmacology·Surabhi ChandraKrishna C Agrawal
Mar 13, 2010·Diabetologia·S JitrapakdeeM J MacDonald
Aug 10, 2010·Critical Reviews in Food Science and Nutrition·Masood Sadiq Butt, Muhammad Tauseef Sultan
Oct 28, 2010·Antioxidants & Redox Signaling·Corinne LeloupLuc Pénicaud
Apr 21, 2011·American Journal of Physiology. Endocrinology and Metabolism·Joshua P GrayEmma Heart
May 18, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Ali Benhaddou-AndaloussiPierre S Haddad
Aug 17, 2011·Journal of Biomedical Science·Ke ChenZhao-hui Mo

❮ Previous
Next ❯

Citations

Apr 3, 2018·Journal of Food Science and Technology·Necla OzdemirAziz Tekin
Sep 7, 2018·Frontiers in Pharmacology·Aminu Mohammed, Md Shahidul Islam
Mar 16, 2019·British Journal of Clinical Pharmacology·Sophie PelegrinHugues Chevassus
May 11, 2018·Oxidative Medicine and Cellular Longevity·Md JakariaDong-Kug Choi
May 7, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yasmina K Mahmoud, Heba M A Abdelrazek

❮ Previous
Next ❯

Related Concepts

Related Feeds