Thymoquinone and fluoxetine alleviate depression via attenuating oxidative damage and inflammatory markers in type-2 diabetic rats

Archives of Physiology and Biochemistry
Mohammed M SafhiTarique Anwer

Abstract

The study was designed to find out the effect of thymoquinone (TQ) alone and combination of TQ + fluoxetine in depression of type-2 diabetic rats. Glucose level was significantly decreased in TQ alone treated group, whereas no significant change was recorded when TQ was combined with fluoxetine. Administration of TQ alone and combination of TQ and fluoxetine significantly decreased immobility time, increased latency to immobility and increased locomotor activity. Treatment with TQ alone significantly decreased level of TBARS, increased GSH and restored the activities of antioxidant enzymes (GPx, GR & CAT). However, TQ and fluoxetine combination reduced TBARS level, increased GSH content but no change in the antioxidant enzymes activities. Inflammatory markers (IL-1β, IL-6 & TNF-α) levels were significantly reduced after the administration of TQ alone and TQ + fluoxetine. The study suggests that combination of TQ and fluoxetine can be used to control depression in type-2 diabetes mellitus.

References

May 26, 2001·Diabetes Care·R J AndersonP J Lustman
Aug 4, 2001·Psychosomatic Medicine·M de GrootP J Lustman
Apr 2, 2003·Biological Trace Element Research·Fakhrul IslamAbdullah Shafique Ahmad
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Dec 8, 2006·Annals of the New York Academy of Sciences·Krystallenia AlexandrakiAnastasios Kalofoutis
May 11, 2007·Brain Research·Alexsandro da Silva HaeserCarmen Regla Vargas
Mar 19, 2008·Basic & Clinical Pharmacology & Toxicology·Tarique AnwerMuzaffar Iqbal
Jun 19, 2008·JAMA : the Journal of the American Medical Association·Sherita Hill GoldenConstantine Lyketsos
Sep 26, 2008·Basic & Clinical Pharmacology & Toxicology·Abdel-Motaal M FoudaOsama A Sharaf El-Din
Nov 12, 2009·Life Sciences·Leelavinothan Pari, Chandrasekaran Sankaranarayanan
Feb 26, 2010·Diabetes Research and Clinical Practice·Leonard E Egede, Charles Ellis
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael Maes
Aug 21, 2013·Environmental Toxicology and Pharmacology·Amita JaswalSangeeta Shukla
Apr 2, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sara DarakhshanSajjad Sisakhtnezhad
Feb 12, 2017·Pharmacological Reports : PR·Urmila AswarManoj Aswar

❮ Previous
Next ❯

Citations

Aug 8, 2019·Archives of Physiology and Biochemistry·Tarique AnwerMohammad Firoz Alam
Mar 23, 2021·Food Science & Nutrition·Masood Sadiq ButtZaffar Mehmood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.