Thymoquinone in the clinical treatment of cancer: Fact or fiction?

Pharmacognosy Reviews
Majed M Abukhader

Abstract

Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa. In vitro and in vivo research has thoroughly investigated the anticancer effects of TQ against several cancer cell lines and animal models. As a result, a considerable amount of information has been generated from research thus providing a better understanding of the anti-proliferating activity of this compound. Therefore, it is appropriate that TQ should move from testing on the bench to clinical experiments. The purpose of this review is to highlight the potential of TQ as an anticancer agent and the chances of this compound in the clinical treatment of cancer, with special attention on breast cancer treatment.

Citations

Apr 5, 2016·Pharmacognosy Magazine·Azza A El-SheikhAzza H Hamouda
Jun 29, 2015·International Immunopharmacology·Amin F Majdalawieh, Muneera W Fayyad
Sep 22, 2016·Journal of Ayurveda and Integrative Medicine·Amin F Majdalawieh, Muneera W Fayyad
Aug 1, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Charlotte M S DetremmeriePaul M Vanhoutte
Oct 5, 2016·Oncology Letters·Lida ZhangYuxiu Yang
Feb 1, 2017·Critical Reviews in Food Science and Nutrition·Amin F MajdalawiehGheyath K Nasrallah
Aug 9, 2018·Journal of Pharmacopuncture·Alireza TavakkoliHossein Hosseinzadeh
Sep 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Banu IskenderHalit Canatan
Mar 7, 2021·International Journal of Molecular Sciences·Noura S Dosoky, William N Setzer
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Adinda Adelia WulandariTri Widiandani

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Methods Mentioned

BETA
transgenic
Fluorescence quenching

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