Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis.

Oxidative Medicine and Cellular Longevity
Hanene Jrah HarzallahTouhami Mahjoub

Abstract

We have performed this study to investigate the modulatory effect of thymoquinone (TQ), the Nigella sativa active compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats. Rats exposed to DMH showed an increase of malondialdehyde and conjugated diene levels, and an augmentation of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also noted. The TQ pretreatment restored the parameters cited above to near-normal values. However, the posttreatment shows an activity similar as that presented by DMH. Therefore, our investigation revealed that TQ was a useful compound preventing DMH-induced erythrocyte damages.

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Citations

May 7, 2013·Asian Pacific Journal of Tropical Biomedicine·Aftab AhmadFiroz Anwar
Oct 1, 2014·Chemico-biological Interactions·Nehal M Elsherbiny, Mohamed El-Sherbiny
Jul 3, 2013·Current Colorectal Cancer Reports·Bharat AggarwalSushovan Guha
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Jul 9, 2014·BioMed Research International·Nandini GautamSunil Mittal
Dec 23, 2014·PloS One·Landa Zeenelabdin Ali SalimSyam Mohan
Oct 10, 2020·Journal of Cancer Prevention·Rohini GomathinayagamDanny N Dhanasekaran

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Methods Mentioned

BETA
MDA
xenograft

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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