Thymosin-induced increase in E-rosette-forming capacity of lymphocytes in patients with malignant neoplasms.

Cancer
H SakalA L Goldstein

Abstract

Thymosin, a thymic hormone, restores decreased cellular immunity under various experimental conditions. The purpose of this study was to evaluate the effect of thymosin on the E-rosette-forming capacity in cancer patients. Peripheral blood lymphocytes obtained from eight patients with various malignant neoplasms were examined. One of these patients received thymosin intramuscularly; his E-rosette formation was examined serially. Eight normal adults served as controls. Patients with advanced stages of malignant tumors showed decreased E-rosette-forming capacity, which increased significantly under the influence of thymosin. Patients with less-advanced tumors, as well as normal adults, demonstrated normal E-rosette formation without further effects by thymosin. The in vivo administration of thymosin to one patient was followed by a marked increase of the E-rosette-forming capacity. These results suggest that the administration of thymosin, both in vivo and in vitro, significantly increases the circulating T-lymphocyte levels and/or functions in patients with advanced malignant neoplasms.

References

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Oct 1, 1973·British Journal of Cancer·B A Khaw, A H Rule
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Aug 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·M ZisblattA White

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Citations

Sep 1, 1977·World Journal of Surgery·J L Rossio, A L Goldstein
Jan 1, 1979·Journal of Immunological Methods·G L Cockerell, C L Baldwin
Apr 1, 1979·The Journal of Clinical Investigation·R E Wolf
Jan 1, 1985·Critical Reviews in Oncology/hematology·R S Schulof
Oct 11, 2012·Annals of the New York Academy of Sciences·Teresa L K LowAllan L Goldstein
Jan 1, 1979·Annals of the New York Academy of Sciences·P B ChretienM H Cohen
Jan 1, 1979·Annals of the New York Academy of Sciences·Y Z PattG Mavligit
Jan 1, 1979·Annals of the New York Academy of Sciences·J CostanziJ Hokanson

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