PMID: 2117278Aug 1, 1990Paper

Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance

Proceedings of the National Academy of Sciences of the United States of America
N FukushiK Onoé

Abstract

Graft-versus-host reaction (GVHR) following allogeneic bone marrow (BM) transplantation was investigated by analyzing expression of antigen receptors on T cells specific for recipient antigens. GVHR chimeras were prepared by transplanting mixtures of splenic T cells and T-cell-depleted BM cells from B10 (I-E-, Mls-1b) or B10.AQR (I-E+, Mls-1b) mice into lethally irradiated AKR/J (I-E+, Mls-1a) recipients. Increased proportions of V beta 6+ T cells reactive to recipient antigens (I-E and Mls-1a) were observed in thymuses from such chimeras 1 or 5 wk after BM transplantation. V beta 6+ T cells observed 1 wk after BM transplantation were derived from mature T cells that had been inoculated into recipients. These cells responded to recipient antigens expressed in the thymus. After 5 wk, thymocytes brightly positive for V beta 6+ were shown not to descend from mature T cells but to differentiate from precursor cells present in the BM inocula. Since V beta 6+ T cells were eliminated in thymuses from non-GVHR chimeras 5 wk after BM transplantation using T-cell-depleted BM cells alone, it appears that GVHR occurring in the thymus at an early stage abrogates thymic stromal functions essential to induction of self-tolerance in the T-cell...Continue Reading

References

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PayneH Hengartner
Jun 1, 1989·European Journal of Immunology·Y YoshikaiK Nomoto
Nov 24, 1989·Science·F RamsdellB J Fowlkes
Jun 1, 1986·Immunological Reviews·J SprentR Korngold
Nov 24, 1988·Nature·H HengartnerR M Zinkernagel
Apr 24, 1987·Cell·J W KapplerP Marrack
Apr 1, 1967·Nature·L R HeimR A Good
Mar 1, 1983·Transplantation Proceedings
Jan 1, 1980·The Journal of Experimental Medicine·K OnoéR A Good
Oct 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W Van EwijkI L Weissman
Feb 18, 1982·The New England Journal of Medicine·R A Good
Jan 1, 1994·Neuroradiology·A C IplikçioğluZ Buharali

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Citations

Apr 1, 1992·Mechanisms of Ageing and Development·M Hartwig
Aug 1, 1994·Mechanisms of Ageing and Development·M Hartwig, G Steinmann
Apr 18, 2007·Nature Reviews. Immunology·Warren D Shlomchik
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Antonia M S MüllerJudith A Shizuru
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H AraseK Onoé
May 1, 1991·The Journal of Experimental Medicine·D B AgusJ Sprent
Apr 20, 1999·The Journal of Experimental Medicine·G DuludeC Perreault
Aug 3, 1999·The Journal of Experimental Medicine·H Kishimoto, J Sprent
Jul 23, 2009·Transplantation·Joon-Ho MoonSang-Kyun Sohn
Nov 30, 2011·TheScientificWorldJournal·Jacopo OlivieriAttilio Olivieri
Apr 1, 1997·Journal of Clinical Pathology·S AractingiE Carosella
May 8, 2002·The Journal of Clinical Investigation·Rainer OrdemannJames L M Ferrara
Mar 5, 2005·Blood·Elizabeth TivolWilliam R Drobyski
May 12, 2011·Disease Models & Mechanisms·Mark A Schroeder, John F DiPersio
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·K NakagawaK Onoé
Nov 1, 2008·Seminars in Immunopathology·Werner Krenger, Georg A Holländer
Feb 3, 1997·The Journal of Experimental Medicine·J P van MeerwijkH R MacDonald
Mar 17, 2012·Journal of the American Academy of Dermatology·Sharon R HymesEdward W Cowen
May 28, 2008·Best Practice & Research. Clinical Haematology·Werner Krenger, Georg A Holländer
Jul 3, 2008·Oral Diseases·M M ImanguliJ C Atkinson
Aug 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elvire BeleokenEric Ballot
Oct 28, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jan StorekDavid G Maloney
Nov 30, 1999·Hematology/oncology Clinics of North America·M E FlowersK M Sullivan
Jan 1, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Takanori TeshimaPaul J Martin
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu-Waye Chu, Ronald E Gress

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