Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Danielle F AtibalentjaE R Unanue

Abstract

Using hen egg-white lysozyme, the effect of blood proteins on CD4 thymic cells was examined. A small fraction of i.v. injected hen egg-white lysozyme rapidly entered the thymus into the medulla. There it was captured and presented by dendritic cells (DCs) to thymocytes from two TCR transgenic mice, one directed to a dominant peptide and a second to a poorly displayed peptide, both presented by MHC class II molecules I-A(k). Presentation by DC led to negative selection and induction of regulatory T cells, independent of epithelial cells. Presentation took place at very low levels, less than 100 peptide-MHC complexes per DC. Such low levels could induce negative selection, but even lower levels could induce regulatory T cells. The anatomy of the thymus-blood barrier, the highly efficient presentation by DC, together with the high sensitivity of thymic T cells to peptide-MHC complexes, results in blood protein Ags having a profound effect on thymic T cells.

References

Jan 1, 1990·International Immunology·J Yagi, C A Janeway
Apr 24, 1987·Cell·J W KapplerP Marrack
Sep 1, 1972·The Journal of Experimental Medicine·E Raviola, M J Karnovsky
May 1, 1994·The Journal of Experimental Medicine·W Y HoM M Davis
Aug 1, 1994·Immunology Today·P G Ashton-Rickardt, S Tonegawa
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·R S LiblauH O McDevitt
Aug 1, 1997·Microscopy Research and Technique·S Kato
Nov 17, 1998·The Journal of Experimental Medicine·G M DaveyK A Hogquist
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D VremecK Shortman
Mar 14, 2000·Current Opinion in Immunology·L Klein, B Kyewski
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P A ReayM M Davis
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C VelazquezE R Unanue
Jan 17, 2002·Journal of Immunological Methods·D H D GrayR L Boyd
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paola RomagnoliJoost P M van Meerwijk
Jun 11, 2002·The Journal of Biological Chemistry·Carlos VelazquezEmil R Unanue
Nov 10, 2004·The Journal of Experimental Medicine·Hisse-Martien van SantenDiane Mathis
Mar 24, 2005·Nature Immunology·Ronald H Schwartz
Jun 11, 2005·Seminars in Immunology·Li Wu, Ken Shortman
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mireille H LahoudMark D Wright
Sep 5, 2006·Nature Immunology·Roberto BonasioUlrich H von Andrian
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie RibotJoost P M van Meerwijk
Nov 9, 2007·Journal of Immunological Methods·Daniel H D GrayAnn P Chidgey

❮ Previous
Next ❯

Citations

Nov 3, 2010·Immunology and Cell Biology·Gerald WirnsbergerLudger Klein
May 29, 2013·The Journal of Experimental Medicine·Jaehak OhJeoung-Sook Shin
May 17, 2014·Nature Reviews. Immunology·Ludger KleinKristin A Hogquist
Jan 31, 2016·Cellular and Molecular Life Sciences : CMLS·Takeshi Nitta, Harumi Suzuki
May 8, 2015·Diabetes·Balasubramanian KrishnamurthyThomas W H Kay
Nov 30, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles J KrogerRoland Tisch
Jul 4, 2015·Immune Network·Jaehak Oh, Jeoung-Sook Shin
Feb 11, 2012·Nature Reviews. Immunology·Chyi-Song HsiehChan-Wang J Lio
Apr 26, 2013·European Journal of Immunology·Husein Hadeiba, Eugene C Butcher
Aug 9, 2016·European Journal of Immunology·Charles J KrogerRoland Tisch
Jan 29, 2020·Annual Review of Immunology·Peter A SavageChristine H Miller
Mar 17, 2010·Immunology and Cell Biology·Sandrine HenriBernard Malissen
Dec 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle F AtibalentjaEmil R Unanue
Mar 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine A WeisslerAndrew J Caton
May 1, 2020·Current Stem Cell Reports·Martin RodriguezGraҫa Almeida-Porada
Sep 8, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Santiago ZelenayJocelyne Demengeot
Jun 19, 2015·Immunological Reviews·Jaehak Oh, Jeoung-Sook Shin
Oct 9, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·David L OwenMichael A Farrar
Jun 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas A SpidaleRoland Tisch
May 15, 2015·Journal of Immunology Research·Ebzadrel Carbajal-FrancoGloria Soldevila
Oct 28, 2020·Seminars in Immunopathology·Piero Alberti, Adam E Handel
Dec 12, 2020·Seminars in Immunopathology·Emilie J CoswayAndrea J White
Feb 2, 2021·Frontiers in Immunology·Takeshi Nitta, Hiroshi Takayanagi
Feb 20, 2021·Frontiers in Immunology·Matthew ClarkRoland M Tisch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Danielle F AtibalentjaE R Unanue
Proceedings of the National Academy of Sciences of the United States of America
Anna I ProiettoLi Wu
European Journal of Immunology
Cristina Cozzo PiccaAndrew J Caton
© 2022 Meta ULC. All rights reserved