PMID: 6028489Aug 1, 1967Paper

Thymus cell migration

The Journal of Experimental Medicine
I L Weissman

Abstract

THE PRECEDING STUDIES HAVE ESTABLISHED THE FOLLOWING POINTS: Intrathymic labeling of thymic lymphocytes provides an adequate marker system to detect the migration of thymus cells to peripheral lymphoid sites. In the newborn, this comprises a major portion of the total lymphocyte population in lymph nodes and spleen. In the adult, this migration is limited to specific portions of lymph nodes and spleen, i.e., those portions which serve the recirculating pool of small lymphocytes. Kinetic studies of labeling within the adult thymus indicate that large cells give rise to medium and small cells, which then migrate to the specific sites noted above. In the newborn, the kinetic pattern is similar to that of adults, with the single distinction that large cells also migrate, accelerating the tempo of migration in these hosts. The long-term fate and function of thymus cell migrants has not yet been determined.

References

Jan 1, 1966·The Journal of Experimental Medicine·D V ParrottJ East
Mar 1, 1966·The Journal of Experimental Medicine·M MatsuyamaD Metcalf
Jul 1, 1966·Transplantation·A J DaviesP C Koller
Jul 1, 1961·The Journal of Endocrinology·F J PEPPER
Sep 29, 1962·British Medical Journal·M BURNET
Nov 17, 1962·Nature·J L GOWANSD M COWEN
Oct 18, 1963·Science·S H ROBINSON, G BRECHER
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J L GOWANS, E J KNIGHT
Jan 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C MARTINEZR A GOOD

❮ Previous
Next ❯

Citations

Sep 1, 1973·The American Journal of Anatomy·L O Simpson
Dec 1, 1975·The Anatomical Record·R M BearmanG D Levine
Jul 25, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·K AbeT Ito
Jan 1, 1984·Developmental and Comparative Immunology·K F Mead, M Borysenko
Jan 1, 1985·International Journal of Radiation Oncology, Biology, Physics·I L Weissman
May 1, 1989·Research in Immunology·M W KieranA Israel
Apr 1, 1991·Current Opinion in Immunology·R Scollay
Oct 1, 1978·Developmental and Comparative Immunology·M BargL R Draper
Aug 23, 2002·Immunological Reviews·Irving L Weissman
Nov 2, 1978·Nature·R ScollayI Weissman
Mar 22, 2006·Nature Immunology·Michael D Cahalan, George A Gutman
Nov 17, 2010·Nature Immunology·Irving Weissman
Aug 5, 1971·The New England Journal of Medicine·C G CraddockR McMillan
Oct 16, 1999·The New England Journal of Medicine·I L Weissman, J A Shizuru
Apr 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nienke VrisekoopKiki Tesselaar
Jan 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·G F Mitchell, J F Miller
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S S ChenJ W Hadden
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C J GuidosB Adkins
Dec 1, 1970·The Journal of Experimental Medicine·J J Owen, M C Raff
Apr 1, 1972·The Journal of Experimental Medicine·D D JoelH Cottier
Feb 1, 1973·The Journal of Experimental Medicine·I L Weissman
Jul 1, 1993·The Journal of Experimental Medicine·D L KraftE K Waller
Apr 1, 1994·The Journal of Experimental Medicine·D F Tough, J Sprent
Apr 1, 1969·British Journal of Haematology·J F Miller
Mar 1, 1974·Cell and Tissue Kinetics·C Röpke, N B Everett
Jan 1, 1977·Cell and Tissue Kinetics·D D JoelJ A Laissue
Aug 1, 1970·Vox Sanguinis·G Goldstein
Jan 1, 1969·Transplantation Reviews·J F Miller, G F Mitchell
Jan 1, 1969·Transplantation Reviews·A J Davies
Jan 1, 1971·Transplantation Reviews·B H Waksman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.