Thymus derived inhibitor of lymphocyte proliferation. I. Isolation and assessment of tissue specificity

Cell and Tissue Kinetics
E O Rijke, R E Ballieux


Preparations from bovine thymus tissue were analyzed for their inhibitory effects during in vitro lymphocyte proliferation. The results indicate that these preparations strongly inhibit DNA synthesis in stimulated human peripheral lymphocytes, bone marrow cells, thymocytes and lymphoblastoid cells. This inhibition was dose-dependent and not due to cytotoxicity of the preparations. No inhibition was found of the spontaneous proliferation of HeLa cells and human fibroblasts indicating that the inhibitory effect was specific for proliferating lymphocytes. Control preparations from bovine liver or kidney did not show any suppression in the test systems used.


Jul 1, 1975·Experimental Cell Research·A M AttallahJ C Houck
Aug 24, 1978·Nature·E O Rijke, R E Ballieux
Aug 1, 1962·Biological Reviews of the Cambridge Philosophical Society·W S BULLOUGH
Jan 1, 1964·Experimental Cell Research·W S BULLOUGH, E B LAURENCE


Jan 1, 1979·Annals of the New York Academy of Sciences·A ReesN Zvaifler
Mar 1, 1984·The Anatomical Record·A L GranataA Corsi

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