PMID: 8977624Dec 27, 1996Paper

Thymus-directed immunotoxicity of airborne dust particles from Upper Silesia (Poland) under acute extrapulmonary studies in mice

Journal of Toxicology and Environmental Health
Ewa KozłowskaK Izdebska-Szymona

Abstract

Industrial air pollutants from Upper Silesia, Poland, contain over 250 polycyclic and heterocyclic aromatic hydrocarbons and heavy metals, including mutagenic and carcinogenic chemicals that have been shown to form DNA adducts. Over 4 million habitants of Silesia are permanently exposed to the industrial pollution by pulmonary and dermal routes and by contaminated food and water. These chemicals, when examined separately in animals models, were proven immunotoxic. We studied the extrapulmonary immunotoxic potential of a typical mixture of Silesian filter-suspended matter from a selected area, over a specific season and time period. Early changes in the immune system were analyzed in BALB/c mice exposed ip to acute doses of 20-330 mg dust mixture/kg body weight (0.06-1.0 LD50). No major changes were noted for weight and the cellularity of spleen, liver and kidneys. However, dramatic decrease in thymus weight index and thymocyte cell count were noted as early as 24-72 h postexposure, which correlated with almost complete depletion of immature, double-positive CD4+CD8+ thymocytes. Changes in spleen were less profound; however, increased depletion of B cells over T cells was noted at high doses of the suspended matter. Exposure to ...Continue Reading

Citations

Apr 5, 2003·Immunopharmacology and Immunotoxicology·Nadzieja Drela, Izabela Ześko
Jan 1, 1999·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals· Leonard I Sweet Dora R Passino-Reader Peter G Meier Geneva M Omann
Jul 22, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Nadzieja Drela
Oct 12, 2002·Immunopharmacology and Immunotoxicology·Nadzieja DrelaPiotr Biernat

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