Thymus graft reconstitution of T-cell-deprived mice infected with Trypanosoma musculi

Parasite Immunology
G A TargettP Viens

Abstract

T-cell-deprived CBA mice were given thymus graft implants during the course of an infection with Trypanosoma musculi and at a time when the parasitaemia was high. As a consequence of the grafts, most of the mice survived the infection whereas control ungrafted mice died. In grafted animals there was generally a period of 60-80 days after grafting during which time parasitic numbers remained high, and a further period of 200 or more days when trypanosomes were still detectable in the circulation. The mice were highly variable in their responses and possible reasons for this are considered.

References

May 1, 1977·Infection and Immunity·R G RankW P Weidanz
Dec 1, 1975·Experimental Parasitology·G A Targett, P Viens
Apr 1, 1975·International Journal for Parasitology·P ViensW H Lumsden
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Jan 1, 1972·Transactions of the Royal Society of Tropical Medicine and Hygiene·P ViensC I Edwards
Jul 1, 1966·Transplantation·A J DaviesP C Koller

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Citations

Jul 16, 2008·Autoimmunity Reviews·A J S Davies

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