PMID: 8968428Jan 1, 1996Paper

Thymus influences liver functions through hypothalamus-pituitary-gonad axis in rats

Advances in Neuroimmunology
L LiS T Xing

Abstract

The aim of the review is to summarize our recent studies on the influence of the thymus on liver functions and its intermediary pathway in rats. Young adult thymectomized rats were used as a model in the experiments, and either thymic peptides or sex hormones were supplemented to these animals. Liver microsomal cytochrome P-450 and aminopyrine-N-demethylase (ADM) activities were decreased in thymectomized rats, and the change in the male was more significant than that in female rats. An increase of liver malondialdehyde (MDA) and a decrease of liver glutathione (GSH) and superoxide dismutase activity were observed in the female thymectomized rats, but not in the males. Accompanied by the increase of MDA, a decline of membrane fluidity of liver microsomes and mitochondria and a decrease of Ca2+ uptake by liver microsomes were exhibited in the female thymectomized rats. Subcutaneous injection of thymic peptides decreased MDA level, and increased GSH content, membrane fluidity and Ca2+ uptake by microsomes in the liver of thymectomized rats. On the other hand, male thymectomized rats showed a decrease of hypothalamic luteinizing hormone-releasing hormone (LHRH), plasma luteinizing hormone (LH) and testosterone levels. Subcutaneous...Continue Reading

References

Jan 1, 1989·Hormone Research·V GeenenP Franchimont
Apr 1, 1987·Steroids·E T Morgan, J A Gustafsson

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Citations

Aug 31, 2014·Microvascular Research·Marco H SantamariaGeert W Schmid-Schönbein

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