PMID: 2105703Feb 1, 1990Paper

Thyroglobulin measurement vs iodine 131 total-body scan for follow-up of well-differentiated thyroid cancer

Archives of Internal Medicine
D P Aiello, A Manni

Abstract

Measurement of the serum thyroglobulin level may be more sensitive than total-body scan using sodium iodide 131 for detecting recurrences from well-differentiated thyroid cancer. We have evaluated the merit of these two methods through a retrospective chart review of patients followed up at the Milton S. Hershey Medical Center, Hershey, Pa. We found that in 17 (45%) of 38 follow-up visits, the presence of interfering antibodies prevented the measurement of serum thyroglobulin levels. Furthermore, such determination was less sensitive than iodine 131 total-body scan in detecting residual thyroid tissue and/or cancer in the neck area. We concluded that iodine 131 total-body scan is the preferable method of follow-up, particularly when the goal of therapy is complete ablation of thyroid tissue.

Citations

Mar 1, 1993·Journal of Endocrinological Investigation·D GiuffridaA Belfiore
Jun 8, 2001·Cancer·S KrishnamurthyN P Caraway
Mar 26, 1999·Cancer·P W GrigsbyB A Siegel
Sep 1, 1995·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·H J Baskin

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