PMID: 9434803Jan 22, 1998Paper

Thyroglobulin peptides of specific primary hormonogenic sites can generate cytotoxic T cells and serve as target autoantigens in experimental autoimmune thyroiditis

Clinical Immunology and Immunopathology
Q WanY C Kong

Abstract

Previously we demonstrated that thyroxine (T4)-containing, 12-mer peptides from positions 5 (1-12) and 2553 (2549-2560), as well as thyronine (T0)-substituted 2553 peptide, derived from human (H) thyroglobulin (Tg) are capable of activating T cells that infiltrate the thyroid (thyroiditogenic). In contrast, peptides T4(2567) and T0(2567) (2559-2570) are not. To determine if these thyroiditogenic peptides, T4(5), T4(2553), and T0(2553), activated cytotoxic T cells (Tc) and served as target autoantigens when loaded onto indicator cells (BW5147 lymphoma, H2k), lymph node cells from CBA mice immunized with mouse (M) Tg were cultured in vitro with MTg, HTg, or Tg peptide. After MTg or HTg activation, Tc were detected for both MTg- and HTg-loaded target cells in an 18-h, 51Cr-release assay at an effector:target cell ratio of 50:1. These Tc also killed target cells labeled with T4(5), T4(2553), or T0(2553), but not the control peptide T4(2567). When MTg-primed lymphocytes were cultured with T4(5), T4(2553), or T0(2553), specific Tc were also generated against target cells labeled with the respective peptide. The data suggest that one of the thyroiditogenic properties of these peptides previously shown by adoptive transfer of thyroidit...Continue Reading

References

Mar 1, 1992·The Journal of Experimental Medicine·P R HutchingsI M Roitt
Feb 1, 1983·The Journal of Experimental Medicine·P CreemersY M Kong
Nov 5, 1997·Clinical Immunology and Immunopathology·P CaturegliN R Rose

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Citations

Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·George Carayanniotis
May 21, 2010·Neurological Research·Lingli YangLingjiang Li
Dec 13, 2003·Neurological Research·Alptekin TaşçiFikret Ergüngör
Mar 12, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L H B BoechatR L Zollner
Dec 29, 2000·International Reviews of Immunology·E A Stafford, N R Rose
Dec 13, 2003·Autoimmunity·George Carayanniotis
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Su He WangJames R Baker
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang D DaiGeorge Carayanniotis
Jun 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Panayota KolypetriGeorge Carayanniotis

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