PMID: 3747940Jan 1, 1986Paper

Thyroid cancer following radiotherapy for Hodgkin's disease: a case report and review of the literature

Medical and Pediatric Oncology
S V Moroff, J Z Fuks

Abstract

Improved survival resulting from advances in therapy in patients with Hodgkin's disease is associated with long-term morbidity, including the potential for the development of a second solid malignancy. We report a 44-year-old man with an unusually aggressive course of thyroid carcinoma 15 years after treatment for Hodgkin's disease. In a review of the English-language literature, we found 21 cases of thyroid cancer following radiotherapy for Hodgkin's disease, with latency periods ranging from 6 to 48 years. The development of secondary thyroid cancer after high-dose neck irradiation may be related to hypothyroidism, itself a complication of radiotherapy. Thyroid function should be measured at least once a year in all patients given neck irradiation, with initiation of thyroid hormone replacement if there is evidence of sustained hypothyroidism.

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Citations

Aug 29, 1991·The New England Journal of Medicine·S L HancockI R McDougall
Sep 17, 2010·Urologic Oncology·Alessandro AntonelliClaudio Simeone
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P F PeerboomP F Bruning
Jul 29, 1998·Medical and Pediatric Oncology·P BlackP Gutjahr
Mar 12, 2005·Journal of the Chinese Medical Association : JCMA·Yi-Chin FongHorng-Chaung Hsu
Sep 1, 1995·British Journal of Sports Medicine·A Combalia-Aleu
Jun 16, 2011·Journal of the American Animal Hospital Association·Jean-Guillaume Grand, Stéphane Claude Bureau
Jan 1, 1987·Medical Oncology and Tumor Pharmacotherapy·Y Najean

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