Thyroid carcinoma-associated genetic mutations also occur in thyroid lymphomas.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Nidhi AggarwalYuri E Nikiforov

Abstract

Molecular testing for mutations activating the mitogen-associated protein kinase signaling pathway is being used to help diagnose thyroid carcinomas. However, the prevalence of these mutations in thyroid lymphomas has not been reported. Therefore, we studied the prevalence of BRAF, NRAS, HRAS, and KRAS mutations in 33 thyroid lymphomas and correlated the mutational status with the clinical, pathological, cytogenetic, and immunophenotypic findings. Eleven cases were also tested for PAX8/PPARγ translocations. The lymphomas included 25 diffuse large B-cell lymphomas, 6 extranodal marginal-zone lymphomas of mucosa-associated lymphoid tissue type, and 2 follicular lymphomas. Seventeen diffuse large B-cell lymphomas were germinal center type, six non-germinal center type, and two unclassifiable (Hans algorithm). None of the cases had an associated thyroid carcinoma. Mutations of the BRAF gene were identified in six (24%) diffuse large B-cell lymphomas (D594G in three germinal center diffuse large B-cell lymphomas, K601N in two germinal center diffuse large B-cell lymphomas, and V600E in one non-germinal center diffuse large B-cell lymphoma) and of the NRAS gene in two (8%) non-germinal center diffuse large B-cell lymphomas (Q61K and ...Continue Reading

References

Oct 1, 1990·Molecular Endocrinology·H NambaJ A Fagin
Sep 1, 1994·Leukemia & Lymphoma·P CorradiniA Pileri
Jan 1, 1996·Histopathology·R K Pedersen, N T Pedersen
Apr 29, 1998·The Netherlands Journal of Medicine·M L HoningC E de Maat
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Apr 17, 2003·Journal of the National Cancer Institute·Yoram CohenDavid Sidransky
Nov 13, 2003·British Journal of Cancer·J W LeeS H Lee
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoram CohenWilliam H Westra
Jun 11, 2005·Endocrine-related Cancer·M Xing
Jul 30, 2005·Current Biology : CB·Natalia MitinChanning J Der
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peng HouMingzhao Xing
Sep 25, 2008·International Journal of Cancer. Journal International Du Cancer·Malihe EskandarpourJohan Hansson
Mar 26, 2009·The Journal of Clinical Endocrinology and Metabolism·Yuri E NikiforovMarina N Nikiforova
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Nov 10, 2009·Thyroid : Official Journal of the American Thyroid Association·Marina N Nikiforova, Yuri E Nikiforov
Nov 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Megan L TroxellChristopher L Corless
Feb 5, 2010·The Journal of Clinical Endocrinology and Metabolism·Silvia CantaraFurio Pacini
Apr 16, 2010·The New England Journal of Medicine·Georg Lenz, Louis M Staudt
Jun 4, 2010·Blood·Gayane Badalian-VeryBarrett J Rollins
Mar 25, 2011·Nature·Michael A ChapmanTodd R Golub
Apr 6, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yuri E Nikiforov
Jun 15, 2011·The New England Journal of Medicine·Enrico TiacciBrunangelo Falini
Nov 1, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lucas MorettiFrancisco Vega
Feb 13, 2013·Clinical and Experimental Dermatology·G W M Millington

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Citations

Jan 4, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Steven H Swerdlow
Jun 30, 2015·Human Pathology·Beenu ThakralL Jeffrey Medeiros
Feb 6, 2014·Blood Cells, Molecules & Diseases·Marcin M Machnicki, Tomasz Stoklosa
Feb 28, 2018·Hematological Oncology·Salvatrice MancusoSergio Siragusa
Jul 25, 2013·The Oncologist·Siun WalshRuth S Prichard
Feb 20, 2020·European Thyroid Journal·Evangelos KarvounisEva Kassi

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