PMID: 16613819Apr 15, 2006Paper

Thyroid carcinoma in children and adolescents: presentation, clinical course, and outcome of therapy in 23 children and adolescents in Northern Greece

Hormones : International Journal of Endocrinology and Metabolism
Kalliopi Pazaitou-PanayiotouGrammati Galaktidou

Abstract

To define clinical presentation, surgical complications, follow-up characteristics, and survival of 23 children and adolescents with thyroid carcinoma. Retrospective analysis of data of 23 children and adolescents with thyroid carcinoma cared for in the Theagenion Cancer Hospital, Thessaloniki. At the time of diagnosis cervical lymph node metastases were present in 18 (78.2%), mediastinal in 2 (8.69%), and pulmonary in 3 patients (13%). Total thyroidectomy was performed in 21 patients, with lymph node dissection in 18 and subtotal thyroidectomy in 2. No significant post-operative complications were observed. Histological examination revealed differentiated thyroid carcinoma (DTC). Tumor was multifocal in 11 (47.8%) and bilateral in 7 subjects (63.6%). Thyroid capsule invasion, vascular invasion, soft tissue involvement, and parathyroid gland invasion was observed in 12 out of 23 patients (52.1%). All patients received thyroxine suppressive therapy and 21 of them additional therapy with radioactive iodine (131I). During follow-up (5.5 years), 6 out of the 23 patients presented new metastases in the cervical and mediastinal lymph nodes, lungs, and bones. At last follow-up, 11 patients (47.8%) had residual disease but all were ali...Continue Reading

Citations

Sep 24, 2010·Thyroid : Official Journal of the American Thyroid Association·Melissa PawelczakBina Shah
Jan 10, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Filipa NeivaSofia Martins
Dec 3, 2014·The Journal of Pediatrics·Kalliopi Pazaitou-PanayiotouFrideriki Patakiouta
Apr 7, 2012·Journal of Oncology·Carla EspadinhaMaria João Bugalho
Sep 7, 2017·Head and Neck Pathology·Justin L BauerLester D R Thompson
Dec 20, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Aybala Agac AyAbdullah Cetin
Jan 1, 2008·Biomarker Insights·Rosaria M RuggeriMaria Trovato
Mar 2, 2019·Journal of the Endocrine Society·Giorgio RadettiAndrea Corrias

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