Thyroid disruption at birth due to prenatal exposure to beta-hexachlorocyclohexane

Environment International
M Alvarez-PedrerolJ Sunyer

Abstract

Thyroid hormones play an important role in human brain development, and some organochlorine compounds (OCs) act as thyroid disruptors. The objective of the present study was to evaluate the association between prenatal exposure to organochlorine compounds and thyroid function in newborns from a general population birth cohort in Menorca, with an a-priori specific focus on beta-HCH. Levels of polychlorinated biphenyls (PCB congeners 28, 52, 101, 118, 138, 153 and 180), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), dichlorodiphenyl dichloroethylene (p'p'-DDE) and dichlorodiphenyl trichloroethane (p'p-DDT) in cord serum, and thyrotropin (TSH) concentration in plasma three days after birth were measured in 387 newborns from Menorca. The TSH concentration was categorized (high or low), except for 27 children whose TSH levels were quantified. Levels of beta-HCH and PCB-153 were positively related to TSH concentrations (gestational age-adjusted coefficient (p-value): 0.26 (p = 0.006) and 0.31 (p = 0.050), respectively). beta-HCH is potentially a new thyroid disrupting compound, deserving special interest in future studies given its high body burden in humans.

References

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Citations

Nov 28, 2012·Environmental Science and Pollution Research International·Maria N ManacaCarlota Dobaño
Aug 27, 2009·Journal of Exposure Science & Environmental Epidemiology·Maria-Jose Lopez-EspinosaFerran Ballester
Aug 31, 2011·Thyroid : Official Journal of the American Thyroid Association·Francoise Brucker-DavisPatrick Fenichel
Apr 8, 2011·International Journal of Epidemiology·Mònica GuxensUNKNOWN INMA Project
Jul 2, 2011·Environmental Health Perspectives·Jordi JulvezPhilippe Grandjean
Aug 1, 2008·PLoS Medicine·Andrea BaccarelliPier Alberto Bertazzi
Nov 28, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Elizabeth N Pearce, Lewis E Braverman
Dec 26, 2013·ISRN Pediatrics·Shilpa Khanna AroraSushan Gupta
Oct 7, 2016·The Science of the Total Environment·Shalini D SoechitramPieter J J Sauer
Mar 25, 2018·Endocrine Connections·Bilal B MughalBarbara A Demeneix
Dec 19, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mahshid GheidarlooMahin Hashemipour
Jun 19, 2019·Environmental Science and Pollution Research International·Gerasimos MakrisPanagiota Pervanidou
Jan 20, 2020·Neurotoxicity Research·Jolene KokrokoBrenda Eskenazi
Nov 30, 2019·International Journal of Molecular Sciences·Suraj KannathAgnieszka Dybala-Defratyka

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