Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions

Aquatic Toxicology
Lisa BaumannHelmut Segner

Abstract

The vertebrate thyroid system is important for multiple developmental processes, including eye development. Thus, its environmentally induced disruption may impact important fitness-related parameters like visual capacities and behaviour. The present study investigated the relation between molecular effects of thyroid disruption and morphological and physiological changes of eye development in zebrafish (Danio rerio). Two test compounds representing different molecular modes of thyroid disruption were used: propylthiouracil (PTU), which is an enzyme-inhibitor of thyroid hormone synthesis, and tetrabromobisphenol A (TBBPA), which interacts with the thyroid hormone receptors. Both chemicals significantly altered transcript levels of thyroid system-related genes (TRα, TRβ, TPO, TSH, DIO1, DIO2 and DIO3) in a compound-specific way. Despite these different molecular response patterns, both treatments resulted in similar pathological alterations of the eyes such as reduced size, RPE cell diameter and pigmentation, which were concentration-dependent. The morphological changes translated into impaired visual performance of the larvae: the optokinetic response was significantly and concentration-dependently decreased in both treatments,...Continue Reading

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Citations

Apr 3, 2019·International Journal of Molecular Sciences·Lisa BaumannLucia Vergauwen
Apr 17, 2020·International Journal of Environmental Research and Public Health·Francesca GoriniFabrizio Bianchi
Apr 26, 2020·International Journal of Molecular Sciences·Henrik HolbechLisa Baumann
Dec 18, 2020·The Science of the Total Environment·Hannes ReinwaldSebastian Eilebrecht
Mar 10, 2020·Molecular and Cellular Endocrinology·Stephan CouderqJean-Baptiste Fini
Apr 23, 2020·Environmental Science & Technology·Evelyn StinckensDries Knapen
Jun 26, 2020·Aquatic Toxicology·Lianguo Chen
May 30, 2021·Environmental Pollution·ZhiChao DangAude Kienzler
Jul 31, 2021·Ecotoxicology and Environmental Safety·Yushu QiuLisu Huang
Jun 11, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sebastian HoffmannKatya Tsaioun
Aug 26, 2020·Environmental Science & Technology·Shaochen PangGuibin Jiang
Jun 26, 2020·Environmental Science & Technology·Dries KnapenLucia Vergauwen

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