Thyroid dysfunction in human immunodeficiency virus-infected children and its correlation with CD4(+) T lymphocyte count

Indian Journal of Endocrinology and Metabolism
Satyakumar ThongamSalam Ranabir

Abstract

Thyroid dysfunction has been reported in human immunodeficiency virus (HIV)-infected individuals including children. Some studies have reported that thyroid dysfunction may be a marker of severity or progression of HIV. The aim was to study thyroid function in HIV-infected children with and without highly active anti-retroviral therapy (HAART). Cross-sectional study carried out at a teaching hospital with Anti-Retroviral Therapy Centre (Centre of Excellence) of National AIDS Control Organization. Thyroid stimulating hormone (TSH), total thyroxine (T4), and total tri-iodothyronine (T3) were analyzed in 60 pediatric HIV cases: 30 on HAART and 30 HAART naive. Correlation of T3, T4, and TSH with CD4 count was assessed. Data reported as mean ± standard deviation and as the number of cases and percentages. Comparison between groups was done by independent sample t-test and χ(2)-test. Spearman's correlation coefficient is used to assess the association between thyroid dysfunction and CD4 count. Thyroid function abnormality was seen in five out of 30 patients in both patients on HAART or without HAART therapy. Among patients on HAART, three had hypothyroidism, and two had biochemical feature of sick euthyroid syndrome. Among the HAART ...Continue Reading

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Citations

May 21, 2016·BioMed Research International·Shujing JiNanping Wu
Apr 25, 2019·Journal of Thyroid Research·Adeseye AkinseteEdamisan Temiye
Jun 1, 2021·Journal of Laboratory Physicians·Joyce YoussefMohamed H Ahmed

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