PMID: 6402617Mar 25, 1983Paper

Thyroid failure and protirelin (thyrotropin-releasing hormone) test abnormalities in depressed outpatients

JAMA : the Journal of the American Medical Association
H A SternbachI Extein

Abstract

Forty-four consecutive outpatients referred to a psychiatric hospital for evaluation of depression and anergia were assessed by means of the protirelin (thyrotropin-releasing hormone) test. Nineteen patients (43%) had a blunted thyrotropin (TSH) response to protirelin, while six patients (13.5%) had augmented TSH responses indicating some degree of hypothyroidism. One patient had a low thyroxine level, while three patients had elevated basal TSH levels. Five of the six patients with augmented TSH responses were found to have antithyroid antibodies. These results suggest that a majority of depressed outpatients have abnormalities on the protirelin test and that the TSH response to protirelin is useful in both confirming a diagnosis of major depression and assessing thyroid status.

Citations

Jul 1, 1987·Psychiatry Research·P J Drinka, S K Voeks
May 1, 1985·Journal of Affective Disorders·H A SternbachE Pekary
Jul 6, 2004·General Hospital Psychiatry·Shelagh A FraserJürgen Unützer
Mar 15, 1989·Biological Psychiatry·K T Brady, R F Anton
Jun 1, 1991·Acta Neuropsychiatrica·M VegtT K Birkenhäger

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