Thyroid function and autoimmunity in Danish pregnant women after an iodine fortification program and associations with obstetric outcomes

European Journal of Endocrinology
Sofie BliddalUlla Feldt-Rasmussen

Abstract

Aberrations in maternal thyroid function and autoimmunity during pregnancy have been associated with negative obstetric outcome. In Denmark, a national iodine fortification program was implemented in the year 2000 with the aim to alleviate the mild-moderate iodine deficiency. Following the iodine implementation, there has been an increase in thyroid autoimmunity in the background population. This study investigates the thyroid status of pregnant Danish women following the iodine fortification program, and a possible association with preterm delivery. Historical cohort study of 1278 randomly selected pregnant Danish women attending the national Down's syndrome screening program. The main outcome measures were thyroid status according to laboratory- and gestational-age-specific reference intervals, and association with risk of abnormal obstetric outcome. Antibody-positivity was defined as an antibody-level (thyroid peroxidase and/or thyroglobulin antibodies) above 60 U/ml. Establishing laboratory-specific gestational-age-dependent reference intervals, we found a prevalence of maternal thyroid dysfunction of 10%-15.8% by use of the cut-off suggested by the American Thyroid Association. Thyroid dysfunction was significantly associa...Continue Reading

References

Sep 9, 2005·The Journal of Clinical Endocrinology and Metabolism·Martin I SurksGilbert H Daniels
May 29, 2008·European Journal of Endocrinology·Chrysoula DosiouLawrence M Crapo
Jul 1, 2008·American Journal of Obstetrics and Gynecology·Geralyn Lambert-MesserlianUNKNOWN FaSTER Research Consortium
Jul 2, 2008·Obstetrics and Gynecology·Jane Cleary-GoldmanMary E D'Alton
Nov 29, 2008·BMJ : British Medical Journal·Charlotte K EkelundUNKNOWN Danish Fetal Medicine Research Group
Dec 25, 2008·The Journal of Clinical Endocrinology and Metabolism·Tuija MännistöEila Suvanto-Luukkonen
Dec 4, 2009·European Journal of Endocrinology·Konstantinos A ToulisIoannis Papadimas
Jun 10, 2010·Nature Reviews. Endocrinology·Daniel Glinoer, Carole A Spencer
Jun 23, 2010·Obstetrics and Gynecology·James E HaddowUNKNOWN First- and Second-Trimester Risk of Aneuploidy (FaSTER) Research Consortium
Jan 22, 2011·Obstetrics and Gynecology·Ghalia AshoorKypros H Nicolaides
Mar 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Roberto NegroAlex Stagnaro-Green
Mar 19, 2011·Trends in Endocrinology and Metabolism : TEM·Jatin PatelKerry Richard
May 12, 2011·BMJ : British Medical Journal·Shakila ThangaratinamArri Coomarasamy
Jul 19, 2011·Journal of Thyroid Research·John H Lazarus
Jul 27, 2011·Thyroid : Official Journal of the American Thyroid Association·Alex Stagnaro-GreenUNKNOWN American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum
Nov 26, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Ulla Feldt-Rasmussen, Elisabeth R Mathiesen
Feb 10, 2012·The New England Journal of Medicine·John H LazarusNicholas J Wald
Mar 21, 2012·Human Reproduction Update·R VissenbergM Goddijn
Jul 25, 2012·European Journal of Endocrinology·Xiaoyan HeBin Wang
Aug 8, 2012·The Journal of Clinical Endocrinology and Metabolism·Leslie De GrootScott Sullivan
Sep 17, 2013·The Journal of Clinical Endocrinology and Metabolism·Tim I M KorevaarRobin P Peeters
Nov 26, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lone B RasmussenLars Ovesen
Dec 24, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Stine Linding AndersenPeter Laurberg

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Citations

Jan 30, 2018·Nutrition & Metabolism·Julie Bienertová-VaškůHynek Pikhart
Feb 9, 2019·Thyroid : Official Journal of the American Thyroid Association·Stine Linding AndersenPeter Vestergaard
Jan 30, 2019·Thyroid : Official Journal of the American Thyroid Association·M Dolores OlleroEmma Anda
Aug 14, 2019·Thyroid : Official Journal of the American Thyroid Association·Sofie BliddalHenriette Svarre Nielsen
Dec 27, 2019·Clinical Endocrinology·Louise KnøsgaardStine Linding Andersen
Dec 7, 2019·Thyroid : Official Journal of the American Thyroid Association·Georgiana SitorisKris Poppe
Nov 18, 2018·Thyroid : Official Journal of the American Thyroid Association·Allan Chen Dong, Alex Stagnaro-Green
Jul 20, 2018·European Thyroid Journal·Flora Veltri, Kris Poppe
Feb 15, 2021·Human Immunology·Raazia TasadduqAbdul-Rauf Shakoori
May 24, 2020·The Lancet. Diabetes & Endocrinology·Arash DerakhshanTim I M Korevaar
May 1, 2021·Clinical Endocrinology·Marianne Skovsager AndersenDorte Glintborg

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