Thyroid function and blood pressure homeostasis in euthyroid subjects

The Journal of Clinical Endocrinology and Metabolism
Olga GumieniakGordon H Williams

Abstract

Overt and subclinical hypothyroidism are associated with increased systemic vascular resistance and hypertension. We examined the relationship between thyroid function and blood pressure homeostasis in euthyroid individuals. A total of 284 subjects (68% hypertensive) consumed high- (200 mmol) and low- (10 mmol) sodium diets, and their blood pressure responses were assessed as percentage change in the mean arterial pressure (MAP). p-Aminohippuric acid clearance was used to estimate effective renal plasma flow. Renal vascular resistance (RVR) was calculated as MAP divided by effective renal plasma flow. Serum free T(4) index (FTI) was lower (P < 0.0001) and TSH was higher (P = 0.046) in hypertensive compared with normotensive subjects independent of other baseline characteristics. FTI (beta = -1.51, P < 0.0001), baseline MAP, and race independently predicted MAP salt sensitivity. The FTI relationship with salt sensitivity adjusted for baseline MAP and race was similar among normotensive (beta = -1.42, P = 0.008) and hypertensive subjects (beta = -1.66, P = 0.0001). FTI correlated negatively with high- (P = 0.0001) and low- (P = 0.008) salt RVR, whereas TSH correlated positively with high- (P = 0.016) and low- (P = 0.012) salt RVR...Continue Reading

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Citations

Jun 26, 2009·Journal of Human Hypertension·D LiuW Teng
Oct 7, 2006·Journal of Human Hypertension·A IqbalR Jorde
Jan 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Tatjana Traub-WeidingerChristian Pirich
Aug 9, 2012·Thyroid : Official Journal of the American Thyroid Association·Eun Sook KimJe Ho Han
Feb 23, 2013·Thyroid : Official Journal of the American Thyroid Association·Till IttermannHenry Völzke
Jan 10, 2012·Journal of Hypertension·Irene LambrinoudakiKimon Stamatelopoulos
Oct 26, 2007·Kidney & Blood Pressure Research·Mehmet KanbayAdrian Covic
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Jan 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Qing-Yin GuoMeng Yang
Jul 15, 2015·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Emily CohodesAlicia Lieberman
Nov 11, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M LaclaustraJ A Casasnovas
Sep 21, 2006·Clinical Endocrinology·John P WalshValdo Michelangeli
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Jul 21, 2017·European Journal of Endocrinology·Mirjana BarjaktarovicRobin P Peeters
Jan 17, 2007·Hypertension·Olga GumieniakGordon H Williams
Jul 26, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Yiyi ZhangEliseo Guallar
Nov 10, 2007·Endocrine Reviews·Bernadette Biondi, David S Cooper
Dec 30, 2011·The Journal of Clinical Endocrinology and Metabolism·Till IttermannHenry Völzke
Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Jose-Manuel Fernández-RealWifredo Ricart
Jan 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Bjørn O AsvoldLars J Vatten
Jan 27, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Bo Hyun ParkHyesook Park

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