Thyroid Function and Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects.

Annals of Hepatology
Yiting LiuXingshun Qi

Abstract

The association between thyroid function and non-alcoholic fatty liver disease (NAFLD) remained controversial. A large cross-sectional study aimed to explore the relationship in euthyroid population. A total of 1773 euthyroid subjects who underwent health check-up during one-year period were enrolled. NAFLD was diagnosed by ultrasound and fatty liver index (FLI). Fibrosis was estimated by BARD score. Thyroid function parameters, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4), were recorded. Multivariate logistic regression analyses were performed to identify the independent risk factors. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. NAFLD was diagnosed by ultrasound in 638 (35.98%) subjects and by FLI ≥ 60 in 694 (39.14%) subjects. Regardless of ultrasound or FLI, the overall analysis demonstrated that TSH and FT3 levels were significantly higher in subjects with NAFLD than subjects without NAFLD, but FT4 level was not significantly different between them. This association remained in middle-age subjects, but not elderly subjects. In the multivariate logistic regression analysis, TSH (OR = 1.108, 95%CI = 1.056-1.398, P = 0.024) and FT3 (OR = 1.258, 95%...Continue Reading

Citations

Jan 8, 2020·Thyroid : Official Journal of the American Thyroid Association·Arjola BanoSalman Razvi
Mar 10, 2019·Journal of Biomedical Science·Hsiang-Cheng ChiKwang-Huei Lin
Nov 17, 2020·Frontiers in Endocrinology·Marta Borges-CanhaDavide Carvalho
May 15, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zhenyu WangLi Wang
Feb 4, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yeqing GuKaijun Niu
Apr 4, 2021·Journal of Clinical Medicine·Alba Martínez-EscudéLlorenç Caballería
Jul 1, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ying TanYanming Chen
Dec 11, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael H LeMindie H Nguyen

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